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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Novel Naproxen Derivatives: Lewis Acid/Transition-metal Free Synthesis via C-C Bond Forming Reaction

Author(s): Sarbani Pal, P. Bindu, Pragnyadhar Reddy Venna and P. K. Dubey

Volume 4, Issue 4, 2007

Page: [292 - 295] Pages: 4

DOI: 10.2174/157017807781024255

Price: $65

Abstract

Naproxen or 2-(6-methoxy naphthalen-2-yl)propionic acid participated in trifluoroacetic anhydride/ phosphoric acid mediated C-C bond forming reaction in a regioselective fashion when treated with a variety of arene or heteroarene under a solvent-free condition affording novel 1-aryl/heteroaryl substituted 2-(6-methoxy naphthalen-2-yl)propan-1-ones in good yields.

Keywords: Naproxen, acylation, trifluoroacetic anhydride, phosphoric acid


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