Abstract
An efficient and facile synthesis of 2-amino-5,6,7,8-tetrahydro-4-arylnaphthalene-1,3- dicarbonitrile and 5-amino-2,3-dihydro-7-aryl-1H-indene-4,6-dicarbonitrile via three-component reaction of cyclohexanone or cyclopentanone, aldehydes and malononitrile under solvent-free conditions using grinding method has been developed. The mild reaction conditions, simple protocol, good yields and cleaner reaction make this protocol practical and economically attractive.
Keywords: 2,6-Dicyanoanilines, tetrahydronaphthalene, dihydroindene, solvent-free condition, multicomponent coupling reaction, grinding
Letters in Organic Chemistry
Title: An Efficient and Facile Synthesis of 2-Amino-5,6,7,8-tetrahydro-4- arylnaphthalene-1,3-dicarbonitrile and 5-Amino-2,3-dihydro-7-aryl-1Hindene- 4,6-dicarbonitrile Via Multicomponent Coupling Reaction Under Solvent-Free Conditions
Volume: 4 Issue: 4
Author(s): Liangce Rong, Haiying Wang, Xiaoyue Li, Fang Yang, Hao, Yao, Shujiang Tu and Daqing Shi
Affiliation:
Keywords: 2,6-Dicyanoanilines, tetrahydronaphthalene, dihydroindene, solvent-free condition, multicomponent coupling reaction, grinding
Abstract: An efficient and facile synthesis of 2-amino-5,6,7,8-tetrahydro-4-arylnaphthalene-1,3- dicarbonitrile and 5-amino-2,3-dihydro-7-aryl-1H-indene-4,6-dicarbonitrile via three-component reaction of cyclohexanone or cyclopentanone, aldehydes and malononitrile under solvent-free conditions using grinding method has been developed. The mild reaction conditions, simple protocol, good yields and cleaner reaction make this protocol practical and economically attractive.
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Cite this article as:
Liangce Rong , Haiying Wang , Xiaoyue Li , Fang Yang , Hao , Yao , Shujiang Tu and Daqing Shi , An Efficient and Facile Synthesis of 2-Amino-5,6,7,8-tetrahydro-4- arylnaphthalene-1,3-dicarbonitrile and 5-Amino-2,3-dihydro-7-aryl-1Hindene- 4,6-dicarbonitrile Via Multicomponent Coupling Reaction Under Solvent-Free Conditions, Letters in Organic Chemistry 2007; 4 (4) . https://dx.doi.org/10.2174/157017807781024219
DOI https://dx.doi.org/10.2174/157017807781024219 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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