Abstract
A series of novel, 2-substituted derivatives of fendiline have been synthesised and their ability to inhibit growth of human leukaemia cells (K562) determined. Of these derivatives, the 2-hydroxy compounds 26 and 27 had a significantly greater inhibitory effect on K562 cells than fendiline.
Keywords: Fendiline, Antileukemic compounds, Diphenylmethanes
Letters in Drug Design & Discovery
Title: Synthesis and Evaluation of 2-Substituted Fendiline Analogues as Antileukemics
Volume: 4 Issue: 4
Author(s): James A. Wilkinson, Steven B. Rossington, Nicholas A. Coe, Nicholas Hirst, Alan T. McGown, John Leonard and Nigel Hussain
Affiliation:
Keywords: Fendiline, Antileukemic compounds, Diphenylmethanes
Abstract: A series of novel, 2-substituted derivatives of fendiline have been synthesised and their ability to inhibit growth of human leukaemia cells (K562) determined. Of these derivatives, the 2-hydroxy compounds 26 and 27 had a significantly greater inhibitory effect on K562 cells than fendiline.
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Cite this article as:
Wilkinson A. James, Rossington B. Steven, Coe A. Nicholas, Hirst Nicholas, McGown T. Alan, Leonard John and Hussain Nigel, Synthesis and Evaluation of 2-Substituted Fendiline Analogues as Antileukemics, Letters in Drug Design & Discovery 2007; 4 (4) . https://dx.doi.org/10.2174/157018007784620068
DOI https://dx.doi.org/10.2174/157018007784620068 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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