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Current Gene Therapy

Editor-in-Chief

ISSN (Print): 1566-5232
ISSN (Online): 1875-5631

Immunotherapy of Human Cancers Using Gene Modified T Lymphocytes

Author(s): Juan F. Vera, Malcolm K. Brenner and Gianpietro Dotti

Volume 9, Issue 5, 2009

Page: [396 - 408] Pages: 13

DOI: 10.2174/156652309789753338

Price: $65

Abstract

Adoptive T cell therapies can produce objective clinical responses in patients with hematologic and solid malignancies. Genetic manipulation of T lymphocytes has been proposed as a means of increasing the potency and range of this anti-tumor activity. We now review how coupling expression of transgenic receptors with countermeasures against potent tumor immune evasion strategies is proving highly effective in pre-clinical models and describe how these approaches are being evaluated in human subjects.


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