Abstract
[1,2,3]-Benzotriazines represent an interesting category of heterocyclic compounds. Various synthetic methods, key reactions and biological aspects have been highlighted. In particular, some analogues have shown antitumor activity. [1,2,3]- Benzotriazin-4-one derivatives are applied extensively as herbicides, insecticides and nematicides. Incorporation of these compounds into the human food chain is a cause of concern, since their toxicity to man is well documented. This review is an attempt to discuss synthesis, chemical reactions, applications and pharmacological aspects of [1,2,3]- benzotriazine analogues from 1957 till date.
Keywords: [1, 2, 3]- Benzotriazines, [1, 2, 3]- BenzotriazineN-oxide, [1, 2, 3]- Benzotriazin-4(3H)-one, 4- Hydroxy- [1, 2, 3]-benzotriazines, coupling agent, HOOBt.
Graphical Abstract
Current Organic Chemistry
Title:Chemistry and Biological Activity of [1,2,3]-Benzotriazine Derivatives
Volume: 22 Issue: 28
Author(s): Ghodsi Mohammadi Ziarani*, Manizheh Mostofi and Negar Lashgari
Affiliation:
- Department of Chemistry, Alzahra University, Tehran, P.O. Box 1993893973,Iran
Keywords: [1, 2, 3]- Benzotriazines, [1, 2, 3]- BenzotriazineN-oxide, [1, 2, 3]- Benzotriazin-4(3H)-one, 4- Hydroxy- [1, 2, 3]-benzotriazines, coupling agent, HOOBt.
Abstract: [1,2,3]-Benzotriazines represent an interesting category of heterocyclic compounds. Various synthetic methods, key reactions and biological aspects have been highlighted. In particular, some analogues have shown antitumor activity. [1,2,3]- Benzotriazin-4-one derivatives are applied extensively as herbicides, insecticides and nematicides. Incorporation of these compounds into the human food chain is a cause of concern, since their toxicity to man is well documented. This review is an attempt to discuss synthesis, chemical reactions, applications and pharmacological aspects of [1,2,3]- benzotriazine analogues from 1957 till date.
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Cite this article as:
Ziarani Mohammadi Ghodsi *, Mostofi Manizheh and Lashgari Negar , Chemistry and Biological Activity of [1,2,3]-Benzotriazine Derivatives, Current Organic Chemistry 2018; 22 (28) . https://dx.doi.org/10.2174/1385272822666181109123711
DOI https://dx.doi.org/10.2174/1385272822666181109123711 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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