Somatostatin sst4 Ligands: Chemistry and Pharmacology

Title: Somatostatin sst4 Ligands: Chemistry and Pharmacology

Volume: 7 Issue: 3

Author(s): A. Michael Crider and Ken A. Witt

Affiliation:

Keywords: somatotropin release-inhibiting factor, Cortistatin, Nonpeptides, CNS disorders, TRPV1 receptor

Abstract: Several classes of compounds (thioureas, ureas, β-glucosides, sulfonamides, and cyclic peptides) show enhanced binding affinity and selectivity at somatostatin subtype 4 receptors (sst4). Pharmacophore models have recently been proposed to explain receptor subtype selectivity. The chemistry and therapeutic potential of sst4 ligands will be the subject of this review.

Cite this article as:

Michael Crider A. and Witt A. Ken, Somatostatin sst4 Ligands: Chemistry and Pharmacology, Mini-Reviews in Medicinal Chemistry 2007; 7 (3) . https://dx.doi.org/10.2174/138955707780059880