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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Atypical GTPases as Drug Targets

Author(s): Meera Soundararajan and Jeyanthy Eswaran

Volume 12, Issue 1, 2012

Page: [19 - 28] Pages: 10

DOI: 10.2174/187152012798764705

Price: $65

Abstract

The Ras GTPases are the founding members of large Ras superfamily, which constitutes more than 150 of these important class of enzymes. These GTPases function as GDP-GTP-regulated binary switches that control many fundamental cellular processes. There are a number of GTPases that have been identified recently, which do not confine to this prototype termed as “atypical GTPases” but have proved to play a remarkable role in vital cellular functions. In this review, we provide an overview of the crucial physiological functions mediated by RGK and Centaurin class of multi domain atypical GTPases. Moreover, the recently available atypical GTPase structures of the two families, regulation, physiological functions and their critical roles in various diseases will be discussed. In summary, this review will highlight the emerging atypical GTPase family which allows us to understand novel regulatory mechanisms and thus providing new avenues for drug discovery programs.

Keywords: Atypical GTPase, Drug target, Anti-cancer agents, lipoylating, Cytoskeletal, Calcium Channel, Centaurins, GTPases, Biomarkers


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