Abstract
Lantadene D was semi-synthetically prepared by functionalizing 22β-hydroxyoleanonic acid and screened for cytotoxicity against four human cancer cell lines (HL-60, HeLa, Colon 502713 and Lung A-549). It was further evaluated for its inhibitory profile against two-stage carcinogenesis in Swiss albino mice.
Keywords: Lantadene D, Cytotoxicity, Antitumor, 12-O- Tetradecanoylphorbol-13 acetate (TPA), 7, 12-Dimethylbenz [a] anthracene (DMBA)
Letters in Drug Design & Discovery
Title: Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D
Volume: 4 Issue: 3
Author(s): Manu Sharma, Pritam Dev Sharma, Mohinder Pal Bansal and Jaswant Singh
Affiliation:
Keywords: Lantadene D, Cytotoxicity, Antitumor, 12-O- Tetradecanoylphorbol-13 acetate (TPA), 7, 12-Dimethylbenz [a] anthracene (DMBA)
Abstract: Lantadene D was semi-synthetically prepared by functionalizing 22β-hydroxyoleanonic acid and screened for cytotoxicity against four human cancer cell lines (HL-60, HeLa, Colon 502713 and Lung A-549). It was further evaluated for its inhibitory profile against two-stage carcinogenesis in Swiss albino mice.
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Cite this article as:
Sharma Manu, Dev Sharma Pritam, Pal Bansal Mohinder and Singh Jaswant, Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077471
DOI https://dx.doi.org/10.2174/157018007780077471 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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