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Current Vascular Pharmacology

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ISSN (Online): 1875-6212

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Review Article

A Narrative Review of Recent Studies on the Role of Vitamin D in the Prevention of Cardiac and Renal Risk and Additional Considerations for COVID-19 Vulnerability

Author(s): Aikaterini E. Panteli, Panagiotis Theofilis, Aikaterini Vordoni, Georgios Vlachopanos, Maria Koukoulaki and Rigas G. Kalaitzidis*

Volume 20, Issue 2, 2022

Published on: 08 December, 2021

Page: [168 - 177] Pages: 10

DOI: 10.2174/1570161119666211119142746

Price: $65

Abstract

The role of vitamin D in maintaining a healthy cardiovascular (CV) and the renal system has received increasing attention. Low vitamin D levels are associated with the incidence of hypertension, cardiac remodeling, and chronic congestive heart failure. Low vitamin D levels also influence renal disease progression and albuminuria deterioration. Moreover, recent research indicates that vitamin D deficiency can be a potential risk factor for coronavirus disease-19 (COVID-19) infection and poorer outcomes. Data are inconclusive as to whether supplementation with vitamin D agents reduces CV disease risk or COVID-19 severity. Conversely, in patients with kidney disease, vitamin D supplementation is associated with an improvement in kidney function and albuminuria. This narrative review considers recent data on the effects of vitamin D on the CV and renal system, as well as its possible role regarding COVID-19 complications.

Keywords: Vitamin D deficiency, cardiovascular risk, heart failure, renal function, albuminuria, COVID-19.

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