Abstract
Epidemiological studies suggest that the cardioprotective properties of olive oil, particularly extra-virgin type, result from a positive influence of its components, such as phenolic compounds, on the cardiovascular system. One of the most abundant phenolic compounds of extra virgin olive oil is the dialdehydic form of elenolic acid conjugated with 3, 4-(dihydroxyphenyl)ethanol (3, 4- DHPEA-EDA), also known as oleacein. Due to its abundance in olive oil, it may play a special role in decreasing the progression of atherosclerosis. Some bioactivities of oleacein, such as antioxidant, anti-inflammatory, anti-proliferative and antimicrobial, were documented. There is also evidence of the bioavailability of oleacein in humans as well. However, due to the lack of clinical data, further studies are needed to provide information about the usefulness of this compound in antiatherosclerotic therapy.
Keywords: 3, 4-DHPEA-EDA, oleacein, Mediterranean diet, atherosclerosis.
Current Pharmaceutical Design
Title:Oleacein. Translation from Mediterranean Diet to Potential Antiatherosclerotic Drug
Volume: 21 Issue: 9
Author(s): Marek Naruszewicz, Monika E. Czerwinska and Anna K. Kiss
Affiliation:
Keywords: 3, 4-DHPEA-EDA, oleacein, Mediterranean diet, atherosclerosis.
Abstract: Epidemiological studies suggest that the cardioprotective properties of olive oil, particularly extra-virgin type, result from a positive influence of its components, such as phenolic compounds, on the cardiovascular system. One of the most abundant phenolic compounds of extra virgin olive oil is the dialdehydic form of elenolic acid conjugated with 3, 4-(dihydroxyphenyl)ethanol (3, 4- DHPEA-EDA), also known as oleacein. Due to its abundance in olive oil, it may play a special role in decreasing the progression of atherosclerosis. Some bioactivities of oleacein, such as antioxidant, anti-inflammatory, anti-proliferative and antimicrobial, were documented. There is also evidence of the bioavailability of oleacein in humans as well. However, due to the lack of clinical data, further studies are needed to provide information about the usefulness of this compound in antiatherosclerotic therapy.
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Cite this article as:
Naruszewicz Marek, Czerwinska E. Monika and Kiss K. Anna, Oleacein. Translation from Mediterranean Diet to Potential Antiatherosclerotic Drug, Current Pharmaceutical Design 2015; 21 (9) . https://dx.doi.org/10.2174/1381612820666141007141137
DOI https://dx.doi.org/10.2174/1381612820666141007141137 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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