Abstract
Proteases have long played a central role in the molecular pathogenesis of Alzheimer ’ s disease (AD), yet proteases that degrade the amyloid β-protein (Aβ) itself were largely ignored until only quite recently. Today, we know that Aβ-degrading proteases are critical regulators of brain Aβ levels in vivo, with evidence accumulating that their dysfunction may play a role in the etiology of AD. This review explores the historical factors that obscured this important aspect of amyloidogenesis, and discusses the many fresh insights it offers into the causes of and potential treatments for AD.
Keywords: Alzheimer's disease, proteases, amyloid, amyloidogenesis, catabolism
Current Alzheimer Research
Title: Proteolytic Degradation of the Amyloid β-Protein: The Forgotten Side of Alzheimers Disease
Volume: 3 Issue: 5
Author(s): Malcolm A. Leissring
Affiliation:
Keywords: Alzheimer's disease, proteases, amyloid, amyloidogenesis, catabolism
Abstract: Proteases have long played a central role in the molecular pathogenesis of Alzheimer ’ s disease (AD), yet proteases that degrade the amyloid β-protein (Aβ) itself were largely ignored until only quite recently. Today, we know that Aβ-degrading proteases are critical regulators of brain Aβ levels in vivo, with evidence accumulating that their dysfunction may play a role in the etiology of AD. This review explores the historical factors that obscured this important aspect of amyloidogenesis, and discusses the many fresh insights it offers into the causes of and potential treatments for AD.
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Leissring A. Malcolm, Proteolytic Degradation of the Amyloid β-Protein: The Forgotten Side of Alzheimers Disease, Current Alzheimer Research 2006; 3 (5) . https://dx.doi.org/10.2174/156720506779025206
DOI https://dx.doi.org/10.2174/156720506779025206 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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