Abstract
Background: Intracerebral hemorrhage is one of the most common injuries in vehicle accidents. The aim of this paper is to survey the injury mechanism of intracerebral hemorrhage in vehicle accidents, including contusion, subarachnoid hemorrhage (SAH), subdural hematoma (SDH) and diffuse axonal injury (DAI).
Methods: A condensed overview is given based on the published studies in biomechanical studies on intracerebral hemorrhage. Animal tests, cadaver tests, accident investigations and numerical simulation are the main method used for the mechanism studies. Results: Angular velocity and acceleration can be used to predict these injuries and they are the main causation of DAI. Intracranial pressure is the main causation of coup/contrecoup contusion. Shear stress and strain contribute to the rupture of bridging veins that result in SDH, SAH. Conclusion: Injury mechanism of intracerebral hemorrhage in vehicle accidents is complicated that with multiple causations. In-depth works need to be carried out in mechanism studies especially for child head injuries.Keywords: Intracerebral hemorrhage, brain injury, vehicle accident, passive safety, subarachnoid hemorrhage (SAH), subdural hematoma (SDH).
Current Pharmaceutical Design
Title:A Review on Injury Mechanism of Intracerebral Hemorrhage in Vehicle Accidents
Volume: 23 Issue: 15
Author(s): Fan Li*, Honggeng Li, Zhi Xiao, Ronggui Lu, Zhiteng Zhang, Haiyun Zhu and Lihai Ren
Affiliation:
- Arts et Metiers, ParisTech, Paris,France
Keywords: Intracerebral hemorrhage, brain injury, vehicle accident, passive safety, subarachnoid hemorrhage (SAH), subdural hematoma (SDH).
Abstract: Background: Intracerebral hemorrhage is one of the most common injuries in vehicle accidents. The aim of this paper is to survey the injury mechanism of intracerebral hemorrhage in vehicle accidents, including contusion, subarachnoid hemorrhage (SAH), subdural hematoma (SDH) and diffuse axonal injury (DAI).
Methods: A condensed overview is given based on the published studies in biomechanical studies on intracerebral hemorrhage. Animal tests, cadaver tests, accident investigations and numerical simulation are the main method used for the mechanism studies. Results: Angular velocity and acceleration can be used to predict these injuries and they are the main causation of DAI. Intracranial pressure is the main causation of coup/contrecoup contusion. Shear stress and strain contribute to the rupture of bridging veins that result in SDH, SAH. Conclusion: Injury mechanism of intracerebral hemorrhage in vehicle accidents is complicated that with multiple causations. In-depth works need to be carried out in mechanism studies especially for child head injuries.Export Options
About this article
Cite this article as:
Li Fan*, Li Honggeng, Xiao Zhi, Lu Ronggui, Zhang Zhiteng, Zhu Haiyun and Ren Lihai, A Review on Injury Mechanism of Intracerebral Hemorrhage in Vehicle Accidents, Current Pharmaceutical Design 2017; 23 (15) . https://dx.doi.org/10.2174/1381612823666161118144829
DOI https://dx.doi.org/10.2174/1381612823666161118144829 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Preface [Hot Topic: New Clinical Applications for Naturally Occurring Peptide Toxins (Guest Editors: Robert Jones / Graeme Semple)]
Current Medicinal Chemistry Recent Advances in Endocrine Metabolic Immune Disorders Drug Targeting: An Editorial Overview
Endocrine, Metabolic & Immune Disorders - Drug Targets Benefits of Chinese Medicine Among Patients with Diabetic Foot: An Expert Review from Clinical Studies
Current Vascular Pharmacology Radiological Diagnosis of Renal Thrombosis in Children
Current Pediatric Reviews Targeting the Coagulation Factor Fibrinogen for Arthritis Therapy
Current Pharmaceutical Biotechnology Cerebral White Matter Injuries Following a Hypoxic/Ischemic Insult During the Perinatal Period: Pathophysiology, Prognostic Factors, and Future Strategy of Treatment Approach. A Minireview
Current Pharmaceutical Design Medicinal Compound Celastrol As a Potential Clinical Anticancer Drug: Lessons Learned From Preclinical Studies
Clinical Cancer Drugs Pharmacological Applications of Antioxidants: Lights and Shadows
Current Drug Targets Future Contrast Agents for Molecular Imaging in Stroke
Current Medicinal Chemistry Channel-Like Functions of the 18-kDa Translocator Protein (TSPO): Regulation of Apoptosis and Steroidogenesis as Part of the Host-Defense Response
Current Pharmaceutical Design Saving the Ischemic Penumbra: Potential Role for Statins and Phosphodiesterase Inhibitors
Current Vascular Pharmacology Limiting Functional Deficiency Following Stroke: Exploiting Different Stem Cell Reservoirs
Current Neuropharmacology Management of Acute Aluminum Phosphide Poisoning: Has Anything Changed?
Drug Metabolism Letters Mast Cell – Glia Dialogue in Chronic Pain and Neuropathic Pain: Blood-Brain Barrier Implications
CNS & Neurological Disorders - Drug Targets Endocannabinoids in Liver Disease and Hepatic Encephalopathy
Current Pharmaceutical Design Mechanisms of Cardioprotection of Halogenated Agents During Extracorporeal Circulation in Cardiac Surgery
Current Vascular Pharmacology Modifiable Midlife Risk Factors for Late-Life Cognitive Impairment and Dementia
Current Psychiatry Reviews Editorial
Current Pediatric Reviews Tumor Necrosis Factor-α-Mediated Pulmonary Endothelial Barrier Dysfunction
Current Respiratory Medicine Reviews Assays for Identification of Hsp90 Inhibitors and Biochemical Methods for Discriminating their Mechanism of Action
Current Topics in Medicinal Chemistry