Abstract
Background: Besides the well-documented biochemical and electrophysiological effects, the mechanical stimuli also have prominent roles in the initiation and development of brain diseases but yet have been underestimated. To explore the role of mechanical stimuli and the followed mechanical-biochemical effects in the brain diseases.
Method: In this review, we discussed the initiation and effect of mechanical stimuli and the surrounding topography in brain diseases, especially for the intracerebral hemorrhage (ICH), Alzheimer’s disease (AD), diffuse axonal injury (DAI) and primary brain tumors. The induced cascades of biological pathways by mechanical stimuli prior to and during the brain diseases were summarized. Strategies aiming to reduce the mechanical stimuli related damages or poor outcomes were also discussed, despite some could only prevent rather than cure. Literatures have indicated mechanical stimuli were the connection between the exogenous mechanotransduction and the inherent biochemical cascades. Therefore, we also reviewed in vitro models in the literatures that simulated the diverse range of mechanical stimuli, which connected the neural network with the tissue engineering, biomaterials and potential therapeutic strategies together. Results: At the microscopic and macroscopic levels, the hydrostatic pressure, tensile/compressive force, shear force, and even the roughness of topography from the physical surrounding exert the influence on the neural network not only by themselves but also through the interaction with other factors, e.g. biochemical or electrophysiological effects. Conclusion: In the clinical management, taking the undervalued mechanical stimuli and the followed mechanical- biochemical effects into consideration are important and inevitable in preventing and treating brain diseases.Keywords: Mechanical stimuli, brain diseases, intracerebral hemorrhage, Alzheimer’s disease, in vitro models, electrophysiological effects.
Current Pharmaceutical Design
Title:The Underestimated Role of Mechanical Stimuli in Brain Diseases and the Relate d In Vitro Models
Volume: 23 Issue: 15
Author(s): Tingwang Guo, Peng Ren, Shilei Hao*Bochu Wang*
Affiliation:
- Bioengineering College, Chongqing University, No. 174, Shapingba Main Street, Chongqing,China
- Bioengineering College, Chongqing University, No. 174, Shapingba Main Street, Chongqing,China
Keywords: Mechanical stimuli, brain diseases, intracerebral hemorrhage, Alzheimer’s disease, in vitro models, electrophysiological effects.
Abstract: Background: Besides the well-documented biochemical and electrophysiological effects, the mechanical stimuli also have prominent roles in the initiation and development of brain diseases but yet have been underestimated. To explore the role of mechanical stimuli and the followed mechanical-biochemical effects in the brain diseases.
Method: In this review, we discussed the initiation and effect of mechanical stimuli and the surrounding topography in brain diseases, especially for the intracerebral hemorrhage (ICH), Alzheimer’s disease (AD), diffuse axonal injury (DAI) and primary brain tumors. The induced cascades of biological pathways by mechanical stimuli prior to and during the brain diseases were summarized. Strategies aiming to reduce the mechanical stimuli related damages or poor outcomes were also discussed, despite some could only prevent rather than cure. Literatures have indicated mechanical stimuli were the connection between the exogenous mechanotransduction and the inherent biochemical cascades. Therefore, we also reviewed in vitro models in the literatures that simulated the diverse range of mechanical stimuli, which connected the neural network with the tissue engineering, biomaterials and potential therapeutic strategies together. Results: At the microscopic and macroscopic levels, the hydrostatic pressure, tensile/compressive force, shear force, and even the roughness of topography from the physical surrounding exert the influence on the neural network not only by themselves but also through the interaction with other factors, e.g. biochemical or electrophysiological effects. Conclusion: In the clinical management, taking the undervalued mechanical stimuli and the followed mechanical- biochemical effects into consideration are important and inevitable in preventing and treating brain diseases.Export Options
About this article
Cite this article as:
Guo Tingwang, Ren Peng, Hao Shilei*, Wang Bochu*, The Underestimated Role of Mechanical Stimuli in Brain Diseases and the Relate d In Vitro Models, Current Pharmaceutical Design 2017; 23 (15) . https://dx.doi.org/10.2174/1381612822666161027113200
DOI https://dx.doi.org/10.2174/1381612822666161027113200 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Intestinal Dysbiosis, Gut Hyperpermeability and Bacterial Translocation: Missing Links Between Depression, Obesity and Type 2 Diabetes
Current Pharmaceutical Design Tailored Multi-Target Agents. Applications and Design Considerations
Current Pharmaceutical Design Polymeric Nanocarriers for Drug Delivery in Osteosarcoma Treatment
Current Pharmaceutical Design Is Human Immunodeficiency Virus-Mediated Dementia an Autophagic Defect that Leads to Neurodegeneration?
CNS & Neurological Disorders - Drug Targets Antitumoral-Lipid-Based Nanoparticles: a Platform for Future Application in Osteosarcoma therapy
Current Pharmaceutical Design New Designer Drugs (Synthetic Cannabinoids and Synthetic Cathinones): Review of Literature
Current Pharmaceutical Design Basic Approaches in Therapy of Multiple Sclerosis (MS) and Related Diseases: Current Achievement and Prospective
Central Nervous System Agents in Medicinal Chemistry Techniques and Methods for In Vivo MRI Monitoring of Exogenous and Endogenous Neural Stem Cell-Mediated Brain Repair
Recent Patents on Regenerative Medicine Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions
Letters in Organic Chemistry Antiretroviral Treatment of HIV Infection Does Not Influence HIVSpecific Immunity but Has an Impact on Non-Specific Immune Activation
Current HIV Research Duloxetine in the Treatment of Depression: An Overview
Central Nervous System Agents in Medicinal Chemistry Strategies for Retargeted Gene Delivery Using Vectors Derived from Lentiviruses
Current Gene Therapy Antisense Strategies
Current Molecular Medicine Regulatory Cascade of Neuronal Loss and Glucose Metabolism
CNS & Neurological Disorders - Drug Targets IgG4 Related Syndrome: Another Multiorgan Disease in the Interest Field of Internal Medicine
Current Pharmaceutical Design Nanotechnology on Duty in Medical Applications
Current Pharmaceutical Biotechnology C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside
Current Neuropharmacology Systematic Evaluation of Drug-Loaded Hydrogels for Application in Osteosarcoma Treatment
Current Pharmaceutical Biotechnology Basic and Clinical Research Against Advanced Glycation End Products (AGEs): New Compounds to Tackle Cardiovascular Disease and Diabetic Complications
Recent Advances in Cardiovascular Drug Discovery (Discontinued) High Dose Immunoglobulin (IVIG) May Reduce the Incidence of Langerhans Cell Histiocytosis (LCH)-Associated Central Nervous System Involvement
CNS & Neurological Disorders - Drug Targets