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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Facile Synthesis of Anticancer Drug NCX 4040 in Mild Conditions

Author(s): Mei Xiao, Hongsong Yang, Suzane M. Klein, Christian M. Muenyi, William L. Stone and Yu L. Jiang

Volume 5, Issue 7, 2008

Page: [510 - 513] Pages: 4

DOI: 10.2174/157017808785982257

Price: $65

Abstract

A simple method is reported to synthesize an anticancer drug, NCX 4040, conveniently in mild conditions using silicon chemistry. A starting material, 4-hydroxybenzyl alcohol, was silylated selectively first to give tbutyldimethylsilyl 4-hydroxybenzyl ether, which was then converted to NCX 4040 by esterification, desilylation, hydrochlorination and nitration.

Keywords: Anticancer drug, NCX 4040, design, synthesis, mild conditions, LNCaP cancer cell lines, prostate cancer

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