Abstract
A hybrid molecule synthesis strategy is employed to develop new molecules with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity.
Keywords: Coumarins, Phthalimides, Naphthalimides and Fluoroquinolone DNA gyrase inhibition
Letters in Drug Design & Discovery
Title: Synthesis and Biological Evaluation of Coumarin Linked Fluoroquinolones, Phthalimides and Naphthalimides as Potential DNA Gyrase Inhibitors
Volume: 3 Issue: 7
Author(s): A. Kamal, M. Satyanarayana, V. Devaiah, V. Rohini, J. S. Yadav, B. Mullick and V. Nagaraja
Affiliation:
Keywords: Coumarins, Phthalimides, Naphthalimides and Fluoroquinolone DNA gyrase inhibition
Abstract: A hybrid molecule synthesis strategy is employed to develop new molecules with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity.
Export Options
About this article
Cite this article as:
Kamal A., Satyanarayana M., Devaiah V., Rohini V., Yadav S. J., Mullick B. and Nagaraja V., Synthesis and Biological Evaluation of Coumarin Linked Fluoroquinolones, Phthalimides and Naphthalimides as Potential DNA Gyrase Inhibitors, Letters in Drug Design & Discovery 2006; 3 (7) . https://dx.doi.org/10.2174/157018006778194862
DOI https://dx.doi.org/10.2174/157018006778194862 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
An Experience with Delamanid in an XDR TB Case – Case Report
Infectious Disorders - Drug Targets Genetic Mapping of Pharmacogenetic Regulatory Variation
Current Pharmaceutical Design Deciphering Role of Cytokines for Therapeutic Strategies Against Rheumatoid Arthritis
Current Drug Targets Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy
Current Medicinal Chemistry Ligand and Structure Based Models for the Identification of Beta 2 Adrenergic Receptor Antagonists
Current Computer-Aided Drug Design Development of Antibacterial Drugs by Targeting Toll-Like Receptors
Current Topics in Medicinal Chemistry Iodocyclization, Followed by Palladium-Catalyzed Coupling: A Versatile Strategy for Heterocyclic Library Construction
Combinatorial Chemistry & High Throughput Screening The Need to Teach Vaccine Safety to Basic Scientists and Public Health Officials
Current Drug Safety Indole and Indoline Scaffolds in Antimicrobials: Overview, Synthesis and Recent Advances in Antimicrobial Research
Current Medicinal Chemistry Computational Sampling and Simulation Based Assessment of Novel <i>Mycobacterium tuberculosis</i> Glutamine Synthetase Inhibitors: Study Involving Structure Based Drug Design and Free Energy Perturbation
Current Topics in Medicinal Chemistry Meet the Editorial Board:
Current Medicinal Chemistry Strain Typing of Mycoplasma pneumoniae and its Value in Epidemiology
Current Pediatric Reviews The Role of Disproportionality Analysis of Pharmacovigilance Databases in Safety Regulatory Actions: a Systematic Review
Current Drug Safety 4-Aminoquinoline Based Molecular Hybrids as Antimalarials: An Overview
Current Topics in Medicinal Chemistry Current Trends in Virtual High Throughput Screening Using Ligand-Based and Structure-Based Methods
Combinatorial Chemistry & High Throughput Screening Meet Our Editorial Board Member
Current Organic Synthesis Adipokines, Metabolism and the Immune Response in the Regulation of Inflammation
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents The Role of Mineral Deficiencies in Insulin Resistance and Obesity
Current Diabetes Reviews Polyphenol Supplementation as a Complementary Medicinal Approach to Treating Inflammatory Bowel Disease
Current Medicinal Chemistry Meet Our Editorial Board Member:
Current Medicinal Chemistry