Abstract
The number of synthetic applications of epoxide hydrolases in organic chemistry has reached a remarkable level. This has been due to a tremendous amount of work dedicated to the discovery of novel epoxide hydrolases from various biological sources, understanding the structure and function of these widespread enzymes and last but not least, the stabilization of these biocatalysts by various means for production purposes.
Keywords: Oxiranes, Enantioselectivity, Enantioconvergence, Kinetic Resolution, Desymmetrization, Asymmetric Synthesis, Biotransformation, Biocatalysis, Vicinal Diol, Chiral Synthon, Building Block, Epoxide hydrolases (EHs), chlorohydrins, epoxides, Aspergillus niger Gbcf 79
Current Organic Chemistry
Title: Epoxide Hydrolases and their Application in Organic Synthesis
Volume: 16 Issue: 4
Author(s): Michael Kotik, Alain Archelas and Roland Wohlgemuth
Affiliation:
Keywords: Oxiranes, Enantioselectivity, Enantioconvergence, Kinetic Resolution, Desymmetrization, Asymmetric Synthesis, Biotransformation, Biocatalysis, Vicinal Diol, Chiral Synthon, Building Block, Epoxide hydrolases (EHs), chlorohydrins, epoxides, Aspergillus niger Gbcf 79
Abstract: The number of synthetic applications of epoxide hydrolases in organic chemistry has reached a remarkable level. This has been due to a tremendous amount of work dedicated to the discovery of novel epoxide hydrolases from various biological sources, understanding the structure and function of these widespread enzymes and last but not least, the stabilization of these biocatalysts by various means for production purposes.
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Cite this article as:
Kotik Michael, Archelas Alain and Wohlgemuth Roland, Epoxide Hydrolases and their Application in Organic Synthesis, Current Organic Chemistry 2012; 16 (4) . https://dx.doi.org/10.2174/138527212799499840
DOI https://dx.doi.org/10.2174/138527212799499840 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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