Abstract
Passerini reaction involving an oxo component, an isocyanide, and a nucleophile in a single step to prepare α-acyloxy carboxamide, was first discovered by Passerini about 90 years ago. Various modifications of this reaction have already been developed such as Lewis acids catalysis, in situ oxidation of alcohols to aldehydes, in situ oxidation of aldehydes to carboxylic acids, direct alkylative Passerini reaction, etc. The Passerini reaction has developed in organic synthesis, the total synthesis of natural products, synthesis of polycyclics, macrocycles, heterocycles and pharmaceutical industry for the synthesis of drug-like compounds. The Passerini products could be later cyclized by another type of ring-closing reaction. The aim of this review is to provide an overview of synthetic applications of Passerini reaction.
Keywords: Passerini reaction, multicomponent reaction, isocyanide, α-acyloxy carboxamide, heterocycles, multicomponent reactions (MCRs), domino process, α-acyloxy carboxamide moiety, macrocycles, carboxylic acid, N-protected amino acid, aliphatic, aromatic, heteroaromatic carboxylic ester derivatives
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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