Abstract
About 300 of steroid drugs have been identified since the research and development to steroid drugs was triggered in 1950s. Although much progress in microbial biotransformation on steroid drugs is well-achieved, many efforts are ongoing in order to improve the efficiency of steroidal drug production as well as to degrade their derivatives. In this work an overview of recent and important findings related to patents and various microbial biotransformations of steroidal compounds including dehydrogenation/reduction, hydroxylation, esterification, methylation, halogenation and methoxylation is presented. Both metabolic pathway and genetic manipulation and screening for new strains capable of metabolizing/transforming steroid drugs, as the powerful endocrine disruptors, are introduced since they are serious environmental contaminants.
Keywords: Biodegradation, biotransformation, dehydrogenation, esterification, halogenations, hydroxylation, metabolic pathway, methylation, methoxylation, reduction
Recent Patents on Biotechnology
Title: Microbial Biotransformation: Recent Developments on Steroid Drugs
Volume: 3 Issue: 2
Author(s): Wang-Yu Tong and Xiang Dong
Affiliation:
Keywords: Biodegradation, biotransformation, dehydrogenation, esterification, halogenations, hydroxylation, metabolic pathway, methylation, methoxylation, reduction
Abstract: About 300 of steroid drugs have been identified since the research and development to steroid drugs was triggered in 1950s. Although much progress in microbial biotransformation on steroid drugs is well-achieved, many efforts are ongoing in order to improve the efficiency of steroidal drug production as well as to degrade their derivatives. In this work an overview of recent and important findings related to patents and various microbial biotransformations of steroidal compounds including dehydrogenation/reduction, hydroxylation, esterification, methylation, halogenation and methoxylation is presented. Both metabolic pathway and genetic manipulation and screening for new strains capable of metabolizing/transforming steroid drugs, as the powerful endocrine disruptors, are introduced since they are serious environmental contaminants.
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Cite this article as:
Tong Wang-Yu and Dong Xiang, Microbial Biotransformation: Recent Developments on Steroid Drugs, Recent Patents on Biotechnology 2009; 3 (2) . https://dx.doi.org/10.2174/187220809788700157
DOI https://dx.doi.org/10.2174/187220809788700157 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
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