Abstract
The majority of the drugs currently employed in the treatment and prophylaxis of malaria are chiral and show enantioselective pharmacodynamic and pharmacokinetic properties in humans and animals. Thus, the assessment of the disposition of these enantiomers in the body using reliable and feasible methods is required to improve the therapy of this disease. Several methods devoted to the enantioselective analysis of the antimalarial drugs and their respective metabolites have been described. Therefore, this article intends to review the methods reported for the enantioselective determination of these analytes with a focus on biological matrices and particular attention will be given to the modern techniques of analysis and sample preparation.
Keywords: Antimalarial drugs, Enantioselective analysis, Sample preparation, Biological matrices
Related Journals
Related Books
New Findings from Natural Substances
Pharmaceutical Chemistry and Production: An Introductory Textbook
Evidence-Based Research in Ayurveda against COVID-19 in Compliance with Standardized Protocols and Practices
Pharmaceuticals for Targeting Coronaviruses
Medical Applications of Beta-Glucan
Nanotechnology Driven Herbal Medicine for Burns: From Concept to Application
Postbiotics: Science, Technology and Applications
Biologically Active Natural Products from Asia and Africa: A Selection of Topics
23