Development of DNA Topoisomerase II-Mediated Anticancer Agents, 3-(9- Acridinylamino)-5-hydroxymethylanilines (AHMAs) and Related Compounds

Title: Development of DNA Topoisomerase II-Mediated Anticancer Agents, 3-(9- Acridinylamino)-5-hydroxymethylanilines (AHMAs) and Related Compounds

Volume: 9 Issue: 18

Author(s): Su Tsann-Long

Affiliation:

Keywords: topoisomerase II, anticancer agents, bio-oxidation, potential clinical application, antitumor acridines, human leukemic ccrfcem cells, computer modelling, sar studies, supercoiled dna

Abstract: A series of potential topoisomerase II-mediated anticancer 9-anilinoacridine derivatives, which are designed to avoid bio-oxidation and possessed long duration of drug action, is reviewed. Among these agents, 3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives and their alkylcarbamates have been investigated and developed for potential clinical application.

Cite this article as:

Tsann-Long Su, Development of DNA Topoisomerase II-Mediated Anticancer Agents, 3-(9- Acridinylamino)-5-hydroxymethylanilines (AHMAs) and Related Compounds, Current Medicinal Chemistry 2002; 9 (18) . https://dx.doi.org/10.2174/0929867023369231