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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Crystal Structures of Acridines Complexed with Nucleic Acids

Author(s): Adrienne Adams

Volume 9, Issue 18, 2002

Page: [1667 - 1675] Pages: 9

DOI: 10.2174/0929867023369259

Price: $65

Abstract

Acridines have been used as chemotherapeutic agents against bacteria, protozoa and fungi, and they now find important use as anticancer drugs. There is a paucity of crystal structures of acridine-DNA complexes above the dinucleotide level, but recent structures of acridinecarboxamide topoisomerase II poisons complexed to hexanucleotides have allowed a molecular rationalization of their structure-activity relationships for cytotoxicity and for their kinetics of DNA binding.

Keywords: acridines, crystal structures, nucleic acids, DNA, complexes, acridine-4-carboxamides


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