Abstract
Hematopoiesis is a complex process during which hematopoietic stem cells (HSC) proliferate and differentiate to constitute both the myeloid and lymphoid branches of the hematopoietic system. Hematopoiesis occurs in successive organs beginning in the yolk sac and aorto-gonads-mesonephros (AGM) region, then migrate from the AGM region to the fetal liver and subsequently to the bone marrow. Hematopoiesis is regulated by a multitude of signals from the microenvironment that control expansion and proper differentiation of blood progenitors. Modifications in gene expression or protein function, as those occurring by chromosome translocations have an oncogenic potential. Over the last decade an increasing number of recurrent chromosomal translocations has been described that are associated with hematologic malignancies. Cloning of the partner genes in these translocations and molecular abnormalities characterization has provided new insights in the processes involved in both normal and malignant hematopoiesis. We review here some of the translocations involved in the pathogenesis of hematologic malignancies with emphasis on what is known regarding the mechanisms of malignant transformation.
Keywords: hematologic malignancy, chromosomal translocation, bcr / abl fusion, tel / abl fusion, hox gene
Current Genomics
Title: Chromosomal Translocations in Hematologic Malignancies
Volume: 3 Issue: 4
Author(s): Claudio G. Brunstein, Scott J. Dylla and Catherine M. Verfaillie
Affiliation:
Keywords: hematologic malignancy, chromosomal translocation, bcr / abl fusion, tel / abl fusion, hox gene
Abstract: Hematopoiesis is a complex process during which hematopoietic stem cells (HSC) proliferate and differentiate to constitute both the myeloid and lymphoid branches of the hematopoietic system. Hematopoiesis occurs in successive organs beginning in the yolk sac and aorto-gonads-mesonephros (AGM) region, then migrate from the AGM region to the fetal liver and subsequently to the bone marrow. Hematopoiesis is regulated by a multitude of signals from the microenvironment that control expansion and proper differentiation of blood progenitors. Modifications in gene expression or protein function, as those occurring by chromosome translocations have an oncogenic potential. Over the last decade an increasing number of recurrent chromosomal translocations has been described that are associated with hematologic malignancies. Cloning of the partner genes in these translocations and molecular abnormalities characterization has provided new insights in the processes involved in both normal and malignant hematopoiesis. We review here some of the translocations involved in the pathogenesis of hematologic malignancies with emphasis on what is known regarding the mechanisms of malignant transformation.
Export Options
About this article
Cite this article as:
Brunstein G. Claudio, Dylla J. Scott and Verfaillie M. Catherine, Chromosomal Translocations in Hematologic Malignancies, Current Genomics 2002; 3 (4) . https://dx.doi.org/10.2174/1389202023350363
DOI https://dx.doi.org/10.2174/1389202023350363 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Evaluating Intestinal Permeability by Measuring Plasma Endotoxin and Diamine Oxidase in Children with Acute Lymphoblastic Leukemia Treated with High-dose Methotrexate
Anti-Cancer Agents in Medicinal Chemistry Alternative Splicing in Chronic Myeloid Leukemia (CML): A Novel Therapeutic Target?
Current Cancer Drug Targets HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Inflammatory Network
Inflammation & Allergy - Drug Targets (Discontinued) CDC25 Inhibitors as Anticancer Agents Are Moving Forward
Anti-Cancer Agents in Medicinal Chemistry Anticancer Agents: VTA or VDA
Current Bioactive Compounds The Use of Therapeutic Peptides to Target and to Kill Cancer Cells
Current Medicinal Chemistry Targeting Microtubules for Cancer Chemotherapy
Current Medicinal Chemistry - Anti-Cancer Agents Molecular Mechanism of Deguelin in Anti-tumor Effect
Current Pharmaceutical Analysis Emerging Family of Protein-protein Interaction Inhibitors Targeting PD-1 Checkpoint Pathway
Current Cancer Therapy Reviews Discovery of Potent Bruton’s Tyrosine Kinase Inhibitors Using Ligand Based Modeling
Anti-Cancer Agents in Medicinal Chemistry Hematopoietic Stem Cell Transplantation for Thalassemia
Current Stem Cell Research & Therapy Perspectives in Medicinal Chemistry: DNA Methylation and Demethylation Mechanisms as Therapeutic Targets?
Current Topics in Medicinal Chemistry Biological Drugs in Guillain-Barré Syndrome: An Update
Current Neuropharmacology Cell-and Gene-based Therapeutic Approaches for Neurological Deficits in Mucopolysaccharidoses
Current Pharmaceutical Biotechnology The Discovery and Development of Selective Estrogen Receptor Modulators (SERMs) for Clinical Practice
Current Clinical Pharmacology Regulation of Platelet Function by Acetylation/Deacetylation Mechanisms
Current Medicinal Chemistry Secondary Neoplasms in Children Treated for Cancer
Current Pediatric Reviews Development of Novel Therapeutics Targeting the Urokinase Plasminogen Activator Receptor (uPAR) and Their Translation Toward the Clinic
Current Pharmaceutical Design Bone Marrow Derived Cells for Brain Repair: Recent Findings and Current Controversies
Current Molecular Medicine Src Kinase Inhibitors: An Update on Patented Compounds
Current Medicinal Chemistry