Abstract
It has been realized for many years that cancer has a genetic component and at the level of the cell it can be said to be a genetic disease. In 1914, Boveri suggested that an aberration in the genome might be responsible for the origin of cancer. This was subsequently supported by the evidence that cancer, or the risk of cancer, could be inherited; that mutagens could cause tumors in both animals and humans, and that tumors are monoclonal in origin, that is, the cells of a tumor all show the genetic characteristics of the original transformed cell. It is only in recent years that the involvement of specific genes has been demonstrated at the molecular level. Cancer cells contain many alterations wich accumulate as tumors develop. Understanding genetic pathways was considered to be, and still remains, the prerequisite for the development of molecular and pharmacological therapeutics to treat and prevent cancer. While researchers in the 20th century focused on the identification of genetic pathways, the beginning of the 21st century will need to focus on the interphase of normal physiology and cancer. Cancer is a disease of the organism, nor simply of abnormal cells. In order to study accurately the complex host-tumor interactions that occur during tumor development, it is necessary to perform experiments in an in vivo setting in which neoplasms emerge in the appropriate microenvironment. While studies in tissue culture cells permit the molecular dissection of pathways operative in a single cell, research in mice integrates the complexity of an organ and its different cell types with the dynamic physiological status of the animal.....
Current Genomics
Title: Overview Section: Genetics of Cancer: Away from the Beaten Track
Volume: 3 Issue: 4
Author(s): Isidro Sanchez-Garcia
Affiliation:
Abstract: It has been realized for many years that cancer has a genetic component and at the level of the cell it can be said to be a genetic disease. In 1914, Boveri suggested that an aberration in the genome might be responsible for the origin of cancer. This was subsequently supported by the evidence that cancer, or the risk of cancer, could be inherited; that mutagens could cause tumors in both animals and humans, and that tumors are monoclonal in origin, that is, the cells of a tumor all show the genetic characteristics of the original transformed cell. It is only in recent years that the involvement of specific genes has been demonstrated at the molecular level. Cancer cells contain many alterations wich accumulate as tumors develop. Understanding genetic pathways was considered to be, and still remains, the prerequisite for the development of molecular and pharmacological therapeutics to treat and prevent cancer. While researchers in the 20th century focused on the identification of genetic pathways, the beginning of the 21st century will need to focus on the interphase of normal physiology and cancer. Cancer is a disease of the organism, nor simply of abnormal cells. In order to study accurately the complex host-tumor interactions that occur during tumor development, it is necessary to perform experiments in an in vivo setting in which neoplasms emerge in the appropriate microenvironment. While studies in tissue culture cells permit the molecular dissection of pathways operative in a single cell, research in mice integrates the complexity of an organ and its different cell types with the dynamic physiological status of the animal.....
Export Options
About this article
Cite this article as:
Sanchez-Garcia Isidro, Overview Section: Genetics of Cancer: Away from the Beaten Track, Current Genomics 2002; 3 (4) . https://dx.doi.org/10.2174/1389202023350390
DOI https://dx.doi.org/10.2174/1389202023350390 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Antidotal Effects of Curcumin Against Agents-Induced Cardiovascular Toxicity
Cardiovascular & Hematological Disorders-Drug Targets Snake Venom: From Deadly Toxins to Life-saving Therapeutics
Current Medicinal Chemistry Anticancer Potential of Ginger: Mechanistic and Pharmaceutical Aspects
Current Pharmaceutical Design MDMA Administration and Heat Shock Proteins Response: Foreseeing a Molecular Link
Current Pharmaceutical Biotechnology Current and Future Applications of Probiotics
Current Nutrition & Food Science Patent Selections
Recent Patents on Anti-Cancer Drug Discovery Synthesis of New Curcumin-like Pentadienones by O- and C-glycosylation
Current Organic Chemistry Role of Inflammation and Tumor Microenvironment in the Development of Gastrointestinal Cancers: What Induced Pluripotent Stem Cells Can Do?
Current Stem Cell Research & Therapy Notch Inhibitors as a New Tool in the War on Cancer: A Pathway to Watch
Current Pharmaceutical Biotechnology The Prognostic and Clinicopathologic Characteristics of OCT4 and Lung Cancer: A Meta-Analysis
Current Molecular Medicine Editorial [Hot Topic: Novel Anti-Cancer Drugs and Therapeutic Approaches (Executive Editor: E. Bergmann-Leitner)]
Current Pharmaceutical Design Application of Machine Learning Approaches for Protein-protein Interactions Prediction
Medicinal Chemistry Meet Our Editorial Board Member
Protein & Peptide Letters Polycation-Based Gene Therapy: Current Knowledge and New Perspectives
Current Gene Therapy Nanoparticles: A Neurotoxicological Perspective
CNS & Neurological Disorders - Drug Targets Small Heat Shock Proteins and Protein-Misfolding Diseases
Current Pharmaceutical Biotechnology In Vivo Pharmacokinetic and Tissue Distribution Studies in Mice of Alternative Formulations for Local and Systemic Delivery of Paclitaxel: Gel, Film, Prodrug, Liposomes and Micelles
Current Drug Delivery Retracted: Potential Health Benefits of Broccoli- A Chemico-Biological Overview
Mini-Reviews in Medicinal Chemistry High-Dose Linoleic Acid Activated JAK2-STAT3 Signaling Pathway Involved in Cytokine Production and Lipogenesis in Pancreatic Exocrine Cells
Current Molecular Medicine Low Utility in Colposcopy-directed Biopsies for Non-high Grade Cytological Abnormalities on PAP Smear
Current Women`s Health Reviews