Abstract
A novel protocol for the semi-synthesis of docetaxel was achieved in four steps from 10-deacetyl baccatin III with an overall yield of 50%. The key step is the selective protection of the C(7) and C(10) hydroxyl groups of 10- deacetyl baccatin III, utilizing benzyl chloromate as a selective protecting reagent, which are capable of being conveniently removed by Pd/C under hydrogen atmosphere.
Keywords: Docetaxel, semi-synthesis, 10-DAB III, benzyl chloromate
Letters in Organic Chemistry
Title: A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III
Volume: 7 Issue: 6
Author(s): Hui Zhou, Dahai Chen, Hongwei Gao and Qingeng Li
Affiliation:
Keywords: Docetaxel, semi-synthesis, 10-DAB III, benzyl chloromate
Abstract: A novel protocol for the semi-synthesis of docetaxel was achieved in four steps from 10-deacetyl baccatin III with an overall yield of 50%. The key step is the selective protection of the C(7) and C(10) hydroxyl groups of 10- deacetyl baccatin III, utilizing benzyl chloromate as a selective protecting reagent, which are capable of being conveniently removed by Pd/C under hydrogen atmosphere.
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Cite this article as:
Zhou Hui, Chen Dahai, Gao Hongwei and Li Qingeng, A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III, Letters in Organic Chemistry 2010; 7 (6) . https://dx.doi.org/10.2174/157017810791824892
DOI https://dx.doi.org/10.2174/157017810791824892 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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