2-Arylindoles: A Privileged Molecular Scaffold with Potent, Broad-Ranging Pharmacological Activity

Title:2-Arylindoles: A Privileged Molecular Scaffold with Potent, Broad-Ranging Pharmacological Activity

Volume: 19 Issue: 28

Author(s): S. Lal and T. J. Snape

Affiliation:

Keywords: 2-arylindoles, biological activity, indoles, privileged structures, drug discovery

Abstract: Privileged structures bind to multiple receptors with high affinity, thus aiding the development of novel biologically active compounds. Indoles are classed as privileged structures, and as a result of the indole nucleus being present in a broad range of biologically active molecules, it has been suggested that indoles probably represent the most important of all structural classes in drug discovery. Amongst the indole class of compounds is a particular subset – 2-arylindoles – which appear to be a most promising lead for drug development. This review summarises the wide-ranging activities of 2-arylindoles and some of their important biological activities reported in the literature over the past two decades.

Cite this article as:

Lal S. and J. Snape T., 2-Arylindoles: A Privileged Molecular Scaffold with Potent, Broad-Ranging Pharmacological Activity, Current Medicinal Chemistry 2012; 19 (28) . https://dx.doi.org/10.2174/092986712803341449