Login Register Cart 0
Generic placeholder image

Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe Translate in Chinese
Mini-Review Article

A Review on Epigenetic Effects of Environmental Factors Causing and Inhibiting Cancer

Author(s): Fatemeh Khaledi and Sorayya Ghasemi*

Volume 22, Issue 1, 2022

Published on: 11 February, 2021

Page: [8 - 24] Pages: 17

DOI: 10.2174/1566524021666210211112800

Price: $65

Abstract

Epigenetic modifications refer to reversible changes in gene expression. Epigenetic changes include DNA methylation, histone modification, and non-coding RNAs that are collectively called epigenome. Various epigenetic effects account for the main impacts of environment and lifestyle on multifactorial diseases, such as cancers. The environmental impacts on cancers act as double-edged swords. While some of them are involved in cancer development, some others contribute to preventing it. In this review article, the keywords "cancer", "epigenetic", "lifestyle", "carcinogen", " cancer inhibitors” and related words were searched to finding a link between environmental factors and epigenetic mechanisms influencing cancer in ISI, PUBMED, SCOPUS, and Google Scholar databases. Based on the literature, environmental factors that are effective in cancer development or cancer prevention will be divided into physical, chemical, biological, and lifestyle types in this review. Different types of epigenetic mechanisms known for each of these agents will be addressed. Unregulated changes in epigenome play roles in tumorigenicity and cancer development. The action mechanism and genes targeted which are related to the signaling pathway for epigenetic alterations determine whether environmental agents are carcinogenic or prevent cancer. Having knowledge about the effective factors and related mechanisms such as epigenetic on cancer can help to prevent and improve cancer treatment.

Keywords: Epigenetic, environment, lifestyle, carcinogen, prevent cancer, gene expression.

« Previous Next »
[1]
You JS, Jones PA. Cancer genetics and epigenetics: Two sides of the same coin? Cancer Cell 2012; 22(1): 9-20.
[http://dx.doi.org/10.1016/j.ccr.2012.06.008] [PMID: 22789535]
[2]
Ghasemi S. Cancer’s epigenetic drugs: Where are they in the cancer medicines? Pharmacogenomics J 2019; 1-13.
[http://dx.doi.org/10.1038/s41397-019-0138-5] [PMID: 31819161]
[3]
Thakur VS, Deb G, Babcook MA, Gupta S. Plant phytochemicals as epigenetic modulators: Role in cancer chemoprevention. AAPS J 2014; 16(1): 151-63.
[http://dx.doi.org/10.1208/s12248-013-9548-5] [PMID: 24307610]
[4]
Fardi M, Solali S, Farshdousti Hagh M. Epigenetic mechanisms as a new approach in cancer treatment: An updated review. Genes Dis 2018; 5(4): 304-11.
[http://dx.doi.org/10.1016/j.gendis.2018.06.003] [PMID: 30591931]
[5]
Nebbioso A, Tambaro FP, Dell’Aversana C, Altucci L. Cancer epigenetics: Moving forward. PLoS Genet 2018; 14(6)e1007362
[http://dx.doi.org/10.1371/journal.pgen.1007362] [PMID: 29879107]
[6]
Baylin SB, Jones PA. Epigenetic determinants of cancer. Cold Spring Harb Perspect Biol 2016; 8(9)a019505
[http://dx.doi.org/10.1101/cshperspect.a019505] [PMID: 27194046]
[7]
Ghasemi S, Razmkhah F, Soleimani M. The role of epigenetics in cancer drug resistance. J Kerman Univ Med Sci 2017; 24(3): 250-8.
[8]
Motamedi M, Hashemzadeh Chaleshtori M, Ghasemi S, Mokarian F. Plasma Level Of miR-21 And miR-451 In Primary And Recurrent Breast Cancer Patients. Breast Cancer (Dove Med Press) 2019; 11: 293-301.
[http://dx.doi.org/10.2147/BCTT.S224333] [PMID: 31749630]
[9]
Mathers JC, Strathdee G, Relton CL. Induction of epigenetic alterations by dietary and other environmental factorsAdvances in genetics Elsevier 2010; 71: pp 3-39
[10]
Kobets T, Iatropoulos MJ, Williams GM. Mechanisms of DNA-reactive and epigenetic chemical carcinogens: Applications to carcinogenicity testing and risk assessment. Toxicol Res (Camb) 2018; 8(2): 123-45.
[http://dx.doi.org/10.1039/C8TX00250A] [PMID: 30997017]
[11]
Tommasi S, Zheng A, Yoon J-I, Besaratinia A. Epigenetic targeting of the Nanog pathway and signaling networks during chemical carcinogenesis. Carcinogenesis 2014; 35(8): 1726-36.
[http://dx.doi.org/10.1093/carcin/bgu026] [PMID: 24480805]
[12]
Taioli E. Gene-environment interaction in tobacco-related cancers. Carcinogenesis 2008; 29(8): 1467-74.
[http://dx.doi.org/10.1093/carcin/bgn062] [PMID: 18550573]
[13]
Marsit CJ, Kim DH, Liu M, et al. Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: Implications for tobacco smoking during adolescence. Int J Cancer 2005; 114(2): 219-23.
[http://dx.doi.org/10.1002/ijc.20714] [PMID: 15540210]
[14]
Jordahl KM, Phipps AI, Randolph TW, et al. Differential DNA methylation in blood as a mediator of the association between cigarette smoking and bladder cancer risk among postmenopausal women. Epigenetics 2019; 14(11): 1065-73.
[http://dx.doi.org/10.1080/15592294.2019.1631112] [PMID: 31232174]
[15]
Murphy SE, Park SL, Balbo S, et al. Tobacco biomarkers and genetic/epigenetic analysis to investigate ethnic/racial differences in lung cancer risk among smokers. NPJ Precision Oncol 2018; 2(1): 1-10.
[16]
Talukdar FR, Ghosh SK, Laskar RS, Mondal R. Epigenetic, genetic and environmental interactions in esophageal squamous cell carcinoma from northeast India. PLoS One 2013; 8(4)e60996
[http://dx.doi.org/10.1371/journal.pone.0060996] [PMID: 23596512]
[17]
He Z, Zhang R, Chen S, et al. FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation Environ Pollut 2019; 252(Pt A): 607-15
[http://dx.doi.org/10.1016/j.envpol.2019.05.137] [PMID: 31185349]
[18]
Martin EM, Fry RC. Environmental influences on the epigenome: exposure-associated DNA methylation in human populations. Annu Rev Public Health 2018; 39: 309-33.
[http://dx.doi.org/10.1146/annurev-publhealth-040617-014629] [PMID: 29328878]
[19]
Tanwar VS, Zhang X, Jagannathan L, Jose CC, Cuddapah S. Cadmium exposure upregulates SNAIL through miR-30 repression in human lung epithelial cells. Toxicol Appl Pharmacol 2019; 373: 1-9.
[http://dx.doi.org/10.1016/j.taap.2019.04.011] [PMID: 30998937]
[20]
He J, Liu W, Ge X, et al. Arsenic-induced metabolic shift triggered by the loss of miR-199a-5p through Sp1-dependent DNA methylation. Toxicol Appl Pharmacol 2019; 378114606
[http://dx.doi.org/10.1016/j.taap.2019.114606] [PMID: 31170415]
[21]
Soza-Ried C, Bustamante E, Caglevic C, Rolfo C, Sirera R, Marsiglia H. Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor. Crit Rev Oncol Hematol 2019; 139: 128-33.
[http://dx.doi.org/10.1016/j.critrevonc.2019.01.012] [PMID: 30878179]
[22]
Salemi R, Marconi A, Di Salvatore V, Franco S, Rapisarda V, Libra M. Epigenetic alterations and occupational exposure to benzene, fibers, and heavy metals associated with tumor development. Review Mol Med Rep 2017; 15(5): 3366-71.
[http://dx.doi.org/10.3892/mmr.2017.6383] [PMID: 28339075]
[23]
Arita A, Costa M. Epigenetics in metal carcinogenesis: Nickel, arsenic, chromium and cadmium. Metallomics 2009; 1(3): 222-8.
[http://dx.doi.org/10.1039/b903049b] [PMID: 20461219]
[24]
Selmin OI, Donovan MG, Skovan B, Paine-Murieta GD, Romagnolo DF. Arsenic induced BRCA1 CpG promoter methylation is associated with the downregulation of ERα and resistance to tamoxifen in MCF7 breast cancer cells and mouse mammary tumor xenografts. Int J Oncol 2019; 54(3): 869-78.
[http://dx.doi.org/10.3892/ijo.2019.4687] [PMID: 30664189]
[25]
Zhou Q, Xi S. A review on arsenic carcinogenesis: Epidemiology, metabolism, genotoxicity and epigenetic changes. Regul Toxicol Pharmacol 2018; 99: 78-88.
[http://dx.doi.org/10.1016/j.yrtph.2018.09.010] [PMID: 30223072]
[26]
Bollati V, Baccarelli A, Hou L, et al. Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res 2007; 67(3): 876-80.
[http://dx.doi.org/10.1158/0008-5472.CAN-06-2995] [PMID: 17283117]
[27]
Peng C, Ng J. The role of epigenetic changes in benzene-induced acute myeloid leukaemia. J Clin Epigenet 2016; 2: 2.
[http://dx.doi.org/10.21767/2472-1158.100019]
[28]
Gao A, Zuo X, Liu Q, Lu X, Guo W, Tian L. Methylation of PARP-1 promoter involved in the regulation of benzene-induced decrease of PARP-1 mRNA expression. Toxicol Lett 2010; 195(2-3): 114-8.
[http://dx.doi.org/10.1016/j.toxlet.2010.03.005] [PMID: 20230882]
[29]
Yang J, Zuo X, Bai W, Niu P, Tian L, Gao A. PTEN methylation involved in benzene-induced hematotoxicity. Exp Mol Pathol 2014; 96(3): 300-6.
[http://dx.doi.org/10.1016/j.yexmp.2014.03.008] [PMID: 24680972]
[30]
Yang J, Bai W, Niu P, Tian L, Gao A. Aberrant hypomethylated STAT3 was identified as a biomarker of chronic benzene poisoning through integrating DNA methylation and mRNA expression data. Exp Mol Pathol 2014; 96(3): 346-53.
[http://dx.doi.org/10.1016/j.yexmp.2014.02.013] [PMID: 24613686]
[31]
Chen J, Zheng Z, Chen Y, et al. Histone deacetylase inhibitors Trichostatin A and MCP30 relieve benzene-induced hematotoxicity via restoring topoisomerase IIα. PLoS One 2016; 11(4)e0153330
[http://dx.doi.org/10.1371/journal.pone.0153330] [PMID: 27058040]
[32]
Bai W, Chen Y, Yang J, Niu P, Tian L, Gao A. Aberrant miRNA profiles associated with chronic benzene poisoning. Exp Mol Pathol 2014; 96(3): 426-30.
[http://dx.doi.org/10.1016/j.yexmp.2014.04.011] [PMID: 24780745]
[33]
Costa M, Davidson TL, Chen H, et al. Nickel carcinogenesis: Epigenetics and hypoxia signaling. Mutat Res 2005; 592(1-2): 79-88.
[http://dx.doi.org/10.1016/j.mrfmmm.2005.06.008] [PMID: 16009382]
[34]
Zhang J, Zhang J, Li M, et al. Methylation of RAR-β2, RASSF1A, and CDKN2A genes induced by nickel subsulfide and nickel-carcinogenesis in rats. Biomed Environ Sci 2011; 24(2): 163-71.
[PMID: 21565688]
[35]
Guo X, Zhang Y, Zhang Q, et al. The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells. Toxicol Ind Health 2016; 32(7): 1286-92.
[http://dx.doi.org/10.1177/0748233714552687] [PMID: 25427687]
[36]
Belinsky SA, Klinge DM, Liechty KC, et al. Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma. Carcinogenesis 2004; 25(6): 1063-7.
[http://dx.doi.org/10.1093/carcin/bgh096] [PMID: 14742312]
[37]
Parkin DM. The global health burden of infection-associated cancers in the year 2002. Int J Cancer 2006; 118(12): 3030-44.
[http://dx.doi.org/10.1002/ijc.21731] [PMID: 16404738]
[38]
Hattori N, Ushijima T. Epigenetic impact of infection on carcinogenesis: Mechanisms and applications. Genome Med 2016; 8(1): 10.
[http://dx.doi.org/10.1186/s13073-016-0267-2] [PMID: 26823082]
[39]
Zhou X, Chen H, Zhu L, et al. Helicobacter pylori infection related long noncoding RNA (lncRNA) AF147447 inhibits gastric cancer proliferation and invasion by targeting MUC2 and up-regulating miR-34c. Oncotarget 2016; 7(50): 82770-82.
[http://dx.doi.org/10.18632/oncotarget.13165] [PMID: 27835575]
[40]
Ding S-Z, Goldberg JB, Hatakeyama M. Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis. Future Oncol 2010; 6(5): 851-62.
[http://dx.doi.org/10.2217/fon.10.37] [PMID: 20465395]
[41]
Lin S, Zhang Y, Hu Y, et al. Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB-mediated expression of CEACAM1-3S in human gastric cancer. Gastric Cancer 2019; 22(5): 941-54.
[http://dx.doi.org/10.1007/s10120-019-00932-0]
[42]
Huang T, Ji Y, Hu D, et al. SNHG8 is identified as a key regulator of epstein-barr virus(EBV)-associated gastric cancer by an integrative analysis of lncRNA and mRNA expression. Oncotarget 2016; 7(49): 80990-1002.
[http://dx.doi.org/10.18632/oncotarget.13167] [PMID: 27835598]
[43]
Liu J, Yang C, Gu Y, et al. Knockdown of the lncRNA SNHG8 inhibits cell growth in Epstein-Barr virus-associated gastric carcinoma. Cell Mol Biol Lett 2018; 23(1): 17.
[http://dx.doi.org/10.1186/s11658-018-0070-8] [PMID: 29736176]
[44]
He B, Zeng J, Chao W, et al. Serum long non-coding RNAs MALAT1, AFAP1-AS1 and AL359062 as diagnostic and prognostic biomarkers for nasopharyngeal carcinoma. Oncotarget 2017; 8(25): 41166-77.
[http://dx.doi.org/10.18632/oncotarget.17083] [PMID: 28467811]
[45]
Ding X, Jia X, Wang C, Xu J, Gao S-J, Lu CA. DHX9-lncRNA-MDM2 interaction regulates cell invasion and angiogenesis of cervical cancer. Cell Death Differ 2019; 26(9): 1750-65.
[http://dx.doi.org/10.1038/s41418-018-0242-0] [PMID: 30518908]
[46]
Mishra S, Husain N, Awasthi NP, Pradeep Y, Roohi R, Saxena S. Liquid-based cytology: do ancillary techniques enhance detection of epithelial abnormalities? Arch Gynecol Obstet 2018; 298(1): 159-69.
[http://dx.doi.org/10.1007/s00404-018-4763-z] [PMID: 29728850]
[47]
Rongrui L, Na H, Zongfang L, Fanpu J, Shiwen J. Epigenetic mechanism involved in the HBV/HCV-related hepatocellular carcinoma tumorigenesis. Curr Pharm Des 2014; 20(11): 1715-25.
[http://dx.doi.org/10.2174/13816128113199990533] [PMID: 23888939]
[48]
Zhang Q, Matsuura K, Kleiner DE, Zamboni F, Alter HJ, Farci P. Analysis of long noncoding RNA expression in hepatocellular carcinoma of different viral etiology. J Transl Med 2016; 14(1): 328.
[http://dx.doi.org/10.1186/s12967-016-1085-4] [PMID: 27894309]
[49]
Farhud DD. Impact of lifestyle on health. Iran J Public Health 2015; 44(11): 1442-4.
[PMID: 26744700]
[50]
Alegría-Torres JA, Baccarelli A, Bollati V. Epigenetics and lifestyle. Epigenomics 2011; 3(3): 267-77.
[http://dx.doi.org/10.2217/epi.11.22] [PMID: 22122337]
[51]
Katzke VA, Kaaks R, Kühn T. Lifestyle and cancer risk. Cancer J 2015; 21(2): 104-10.
[http://dx.doi.org/10.1097/PPO.0000000000000101] [PMID: 25815850]
[52]
Shankar E, Gupta K, Gupta S. Dietary and lifestyle factors in epigenetic regulation of cancer. Epigenet Cancer Prevent Elsevier 2019; pp. 361-94.
[http://dx.doi.org/10.1016/B978-0-12-812494-9.00017-2]
[53]
Mani I. Annual Review of Nutrition, 2015 In; JSTOR2016
[54]
Su LJ, Mahabir S, Ellison GL, McGuinn LA, Reid BC. Epigenetic contributions to the relationship between cancer and dietary intake of nutrients, bioactive food components, and environmental toxicants. Front Genet 2012; 2: 91.
[http://dx.doi.org/10.3389/fgene.2011.00091] [PMID: 22303385]
[55]
Wang T-H, Hsia S-M, Shih Y-H, Shieh T-M. Association of smoking, alcohol use, and betel quid chewing with epigenetic aberrations in cancers. Int J Mol Sci 2017; 18(6): 1210.
[http://dx.doi.org/10.3390/ijms18061210] [PMID: 28587272]
[56]
Masri S, Kinouchi K, Sassone-Corsi P. Circadian clocks, epigenetics, and cancer. Curr Opin Oncol 2015; 27(1): 50-6.
[http://dx.doi.org/10.1097/CCO.0000000000000153] [PMID: 25405464]
[57]
Reiche EMV, Morimoto HK, Nunes SMV. Stress and depression-induced immune dysfunction: implications for the development and progression of cancer. Int Rev Psychiatry 2005; 17(6): 515-27.
[http://dx.doi.org/10.1080/02646830500382102] [PMID: 16401550]
[58]
Bortolato B, Hyphantis TN, Valpione S, et al. Depression in cancer: The many biobehavioral pathways driving tumor progression. Cancer Treat Rev 2017; 52: 58-70.
[http://dx.doi.org/10.1016/j.ctrv.2016.11.004] [PMID: 27894012]
[59]
Lima EM, Leal MF, Burbano RR, et al. Methylation status of ANAPC1, CDKN2A and TP53 promoter genes in individuals with gastric cancer. Braz J Med Biol Res 2008; 41(6): 539-43.
[http://dx.doi.org/10.1590/S0100-879X2008000600017] [PMID: 18622497]
[60]
Mir MR, Shabir N, Wani KA, et al. Association between p16, hMLH1 and E-cadherin promoter hypermethylation and intake of local hot salted tea and sun-dried foods in Kashmiris with gastric tumors. Asian Pac J Cancer Prev 2012; 13(1): 181-6.
[http://dx.doi.org/10.7314/APJCP.2012.13.1.181] [PMID: 22502664]
[61]
Yuasa Y, Nagasaki H, Akiyama Y, et al. Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. Carcinogenesis 2005; 26(1): 193-200.
[http://dx.doi.org/10.1093/carcin/bgh304] [PMID: 15498792]
[62]
Zhou Y, Li R, Yu H, Wang R, Shen Z. microRNA-130a is an oncomir suppressing the expression of CRMP4 in gastric cancer. OncoTargets Ther 2017; 10: 3893-905.
[http://dx.doi.org/10.2147/OTT.S139443] [PMID: 28831264]
[63]
Herceg Z. Epigenetics and cancer: Towards an evaluation of the impact of environmental and dietary factors. Mutagenesis 2007; 22(2): 91-103.
[http://dx.doi.org/10.1093/mutage/gel068] [PMID: 17284773]
[64]
Chen J, Huang Z-J, Duan Y-Q, Xiao X-R, Jiang J-Q, Zhang R. Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism and folate intake in esophageal squamous cell carcinoma. Asian Pac J Cancer Prev 2012; 13(10): 5303-6.
[http://dx.doi.org/10.7314/APJCP.2012.13.10.5303] [PMID: 23244153]
[65]
Hussain S, Singh N, Salam I, et al. Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley. J Recept Signal Transduct Res 2011; 31(2): 147-56.
[http://dx.doi.org/10.3109/10799893.2011.553836] [PMID: 21385099]
[66]
Sidhu S, Deep JS, Sobti R, Sharma V, Thakur H. Methylation pattern of MGMT gene in relation to age, smoking, drinking and dietary habits as epigenetic biomarker in prostate cancer patients. Genet Eng Biotechnol J 2010; 8: 1-11.
[67]
Taniguchi H, Fernández AF, Setién F, et al. Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies. Cancer Res 2009; 69(21): 8447-54.
[http://dx.doi.org/10.1158/0008-5472.CAN-09-0551] [PMID: 19861541]
[68]
Yeh C-M, Shay J, Zeng T-C, et al. Epigenetic silencing of ARNTL, a circadian gene and potential tumor suppressor in ovarian cancer. Int J Oncol 2014; 45(5): 2101-7.
[http://dx.doi.org/10.3892/ijo.2014.2627] [PMID: 25175925]
[69]
Xiang S, Dauchy RT, Hoffman AE, et al. Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer. J Pineal Res 2019; 67(2)e12586
[http://dx.doi.org/10.1111/jpi.12586] [PMID: 31077613]
[70]
Fu A, Leaderer D, Zheng T, Hoffman AE, Stevens RG, Zhu Y. Genetic and epigenetic associations of circadian gene TIMELESS and breast cancer risk. Mol Carcinog 2012; 51(12): 923-9.
[http://dx.doi.org/10.1002/mc.20862] [PMID: 22006848]
[71]
Meeran SM, Ahmed A, Tollefsbol TO. Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clin Epigenetics 2010; 1(3-4): 101-16.
[http://dx.doi.org/10.1007/s13148-010-0011-5] [PMID: 21258631]
[72]
Pop S, Enciu AM, Tarcomnicu I, Gille E, Tanase C. Phytochemicals in cancer prevention: Modulating epigenetic alterations of DNA methylation. Phytochem Rev 2019; 18(4): 1005-24.
[http://dx.doi.org/10.1007/s11101-019-09627-x]
[73]
Li Y, Yuan Y-Y, Meeran SM, Tollefsbol TO. Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. Mol Cancer 2010; 9(1): 274.
[http://dx.doi.org/10.1186/1476-4598-9-274] [PMID: 20946668]
[74]
Montgomery M, Srinivasan A. Epigenetic gene regulation by dietary compounds in cancer prevention. Adv Nutr 2019; 10(6): 1012-28.
[http://dx.doi.org/10.1093/advances/nmz046] [PMID: 31100104]
[75]
Pandey M, Shukla S, Gupta S. Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells. Int J Cancer 2010; 126(11): 2520-33.
[http://dx.doi.org/10.1002/ijc.24988] [PMID: 19856314]
[76]
Shankar E, Iqbal O, Bhaskaran N, et al. Epigenetic modifications involving reactivation of RECK inhibiting MMP-9 and MMP-2 in prostate cancer. AACR 2019.
[77]
Shanmugam MK, Arfuso F, Sng JC, Bishayee A, Kumar AP, Sethi G. Epigenetic effects of curcumin in cancer prevention Epigenetics of Cancer Prevention. Elsevier 2019; pp. 107-28.
[http://dx.doi.org/10.1016/B978-0-12-812494-9.00005-6]
[78]
Majid S, Kikuno N, Nelles J, et al. Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification. Cancer Res 2008; 68(8): 2736-44.
[http://dx.doi.org/10.1158/0008-5472.CAN-07-2290] [PMID: 18413741]
[79]
Xie Q, Bai Q, Zou LY, et al. Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells. Genes Chromosomes Cancer 2014; 53(5): 422-31.
[http://dx.doi.org/10.1002/gcc.22154] [PMID: 24532317]
[80]
Li Y, Chen H, Hardy TM, Tollefsbol TO. Epigenetic regulation of multiple tumor-related genes leads to suppression of breast tumorigenesis by dietary genistein. PLoS One 2013; 8(1)e54369
[http://dx.doi.org/10.1371/journal.pone.0054369] [PMID: 23342141]
[81]
Izquierdo-Torres E, Hernández-Oliveras A, Meneses-Morales I, Rodríguez G, Fuentes-García G, Zarain-Herzberg Á. Resveratrol up-regulates ATP2A3 gene expression in breast cancer cell lines through epigenetic mechanisms. Int J Biochem Cell Biol 2019; 113: 37-47.
[http://dx.doi.org/10.1016/j.biocel.2019.05.020] [PMID: 31173924]
[82]
Chatterjee B, Ghosh K, Kanade SR. Resveratrol modulates epigenetic regulators of promoter histone methylation and acetylation that restores BRCA1, p53, p21CIP1 in human breast cancer cell lines. Biofactors 2019; 45(5): 818-29.
[http://dx.doi.org/10.1002/biof.1544] [PMID: 31317586]
[83]
Dhar S, Hicks C, Levenson AS. Resveratrol and prostate cancer: Promising role for microRNAs. Mol Nutr Food Res 2011; 55(8): 1219-29.
[http://dx.doi.org/10.1002/mnfr.201100141] [PMID: 21714127]
[84]
Liu X, Li H, Wu M-L, et al. Resveratrol reverses retinoic acid resistance of anaplastic thyroid cancer cells via demethylating CRABP2 gene. Front Endocrinol (Lausanne) 2019; 10: 734.
[http://dx.doi.org/10.3389/fendo.2019.00734] [PMID: 31736873]
[85]
Zhang C, Su Z-Y, Khor TO, Shu L, Kong A-NT. Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation. Biochem Pharmacol 2013; 85(9): 1398-404.
[http://dx.doi.org/10.1016/j.bcp.2013.02.010] [PMID: 23416117]
[86]
Su Z-Y, Zhang C, Lee JH, et al. Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane. Cancer Prev Res (Phila) 2014; 7(3): 319-29.
[http://dx.doi.org/10.1158/1940-6207.CAPR-13-0313-T] [PMID: 24441674]
[87]
Fortunati N, Marano F, Bandino A, Frairia R, Catalano MG, Boccuzzi G. The pan-histone deacetylase inhibitor LBH589 (panobinostat) alters the invasive breast cancer cell phenotype. Int J Oncol 2014; 44(3): 700-8.
[http://dx.doi.org/10.3892/ijo.2013.2218] [PMID: 24366407]
[88]
Yu X-D, Wang S-Y, Chen GA, et al. Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells. Cancer J 2007; 13(2): 105-13.
[http://dx.doi.org/10.1097/PPO.0b013e318046eedc] [PMID: 17476138]
[89]
Rozek LS, Virani S, Bellile EL, et al. Soy isoflavone supplementation increases long interspersed nucleotide element-1 (LINE-1) methylation in head and neck squamous cell carcinoma. Nutr Cancer 2019; 71(5): 772-80.
[http://dx.doi.org/10.1080/01635581.2019.1577981] [PMID: 30862188]
[90]
Chen L, Jiang B, Zhong C, et al. Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. Carcinogenesis 2018; 39(3): 471-81.
[http://dx.doi.org/10.1093/carcin/bgy009] [PMID: 29361151]
[91]
Garagnani P, Pirazzini C, Franceschi C. Colorectal cancer microenvironment: among nutrition, gut microbiota, inflammation and epigenetics. Curr Pharm Des 2013; 19(4): 765-78.
[http://dx.doi.org/10.2174/138161213804581981] [PMID: 23016865]
[92]
Bultman SJ. Interplay between diet, gut microbiota, epigenetic events, and colorectal cancer. Mol Nutr Food Res 2017; 61(1)1500902
[http://dx.doi.org/10.1002/mnfr.201500902] [PMID: 27138454]
[93]
Hullar MA, Fu BC. Diet, the gut microbiome, and epigenetics. Cancer J 2014; 20(3): 170-5.
[http://dx.doi.org/10.1097/PPO.0000000000000053] [PMID: 24855003]
[94]
Zimmer P, Baumann FT, Bloch W, et al. Impact of exercise on pro inflammatory cytokine levels and epigenetic modulations of tumor-competitive lymphocytes in Non-Hodgkin-Lymphoma patients-randomized controlled trial. Eur J Haematol 2014; 93(6): 527-32.
[http://dx.doi.org/10.1111/ejh.12395] [PMID: 24913351]
[95]
Boyne DJ, King WD, Brenner DR, McIntyre JB, Courneya KS, Friedenreich CM. Aerobic exercise and DNA methylation in postmenopausal women: an ancillary analysis of the alberta physical activity and breast cancer prevention (ALPHA) trial. PLoS One 2018; 13(6)e0198641
[http://dx.doi.org/10.1371/journal.pone.0198641] [PMID: 29953441]
[96]
Tobias GC, Gomes JLP, Soci UPR, Fernandes T, de Oliveira EM. A Landscape of Epigenetic Regulation by MicroRNAs to the Hallmarks of Cancer and Cachexia: Implications of Physical Activity to Tumor Regression. Epigenetics. IntechOpen 2019.
[97]
Dimauro I, Paronetto MP, Caporossi D. Epigenomic adaptations of exercise in the control of metabolic disease and cancer Nutritional Epigenomics. Elsevier 2019; pp. 289-316.
[http://dx.doi.org/10.1016/B978-0-12-816843-1.00018-7]
[98]
Zhang FF, Cardarelli R, Carroll J, et al. Physical activity and global genomic DNA methylation in a cancer-free population. Epigenetics 2011; 6(3): 293-9.
[http://dx.doi.org/10.4161/epi.6.3.14378] [PMID: 21178401]
[99]
Zeng H, Irwin ML, Lu L, et al. Physical activity and breast cancer survival: an epigenetic link through reduced methylation of a tumor suppressor gene L3MBTL1. Breast Cancer Res Treat 2012; 133(1): 127-35.
[http://dx.doi.org/10.1007/s10549-011-1716-7] [PMID: 21837478]
[100]
Ntanasis-Stathopoulos J, Tzanninis JG, Philippou A, Koutsilieris M. Epigenetic regulation on gene expression induced by physical exercise. J Musculoskelet Neuronal Interact 2013; 13(2): 133-46.
[PMID: 23728100]
[101]
Kumar M, Nagpal R, Verma V, et al. Probiotic metabolites as epigenetic targets in the prevention of colon cancer. Nutr Rev 2013; 71(1): 23-34.
[http://dx.doi.org/10.1111/j.1753-4887.2012.00542.x] [PMID: 23282249]
[102]
Kanwal R, Gupta S. Epigenetic modifications in cancer. Clin Genet 2012; 81(4): 303-11.
[http://dx.doi.org/10.1111/j.1399-0004.2011.01809.x] [PMID: 22082348]
[103]
Shim E-J, Lee JW, Cho J, et al. Association of depression and anxiety disorder with the risk of mortality in breast cancer: A National Health Insurance Service study in Korea. Breast Cancer Res Treat 2020; 179(2): 491-8.
[http://dx.doi.org/10.1007/s10549-019-05479-3] [PMID: 31673880]
[104]
Yang Z-H, Dang Y-Q, Ji G. Role of epigenetics in transformation of inflammation into colorectal cancer. World J Gastroenterol 2019; 25(23): 2863-77.
[http://dx.doi.org/10.3748/wjg.v25.i23.2863] [PMID: 31249445]
[105]
Samanta S, Rajasingh S, Cao T, Dawn B, Rajasingh J. Epigenetic dysfunctional diseases and therapy for infection and inflammation. Biochim Biophys Acta Mol Basis Dis 2017; 1863(2): 518-28.
[http://dx.doi.org/10.1016/j.bbadis.2016.11.030] [PMID: 27919711]

Rights & Permissions Print Cite
Article Metrics
33
3
© 2024 Bentham Science Publishers | Privacy Policy