Improvement of Tumor Localization of Photosensitizers for Photodynamic Therapy and Its Application for Tumor Diagnosis

Title: Improvement of Tumor Localization of Photosensitizers for Photodynamic Therapy and Its Application for Tumor Diagnosis

Volume: 12 Issue: 3

Author(s): Shun-Ichiro Ogura, Yuichiro Hagiya, Kenji Tabata, Toshiaki Kamachi and Ichiro Okura

Affiliation:

Keywords: Photodynamic therapy, phthalocyanine, aminolevulinic acid, immunoconjugate, photodynamic diagnosis, tumor marker, porphyrin 5-aminolevulinic acid, ophthalmic tumors, fluorescence diagnosis, target tissues, photosensitizer, hematoporphyrin derivative, tumor tissue occurs, hemoglobin, photodynamic treatment

Abstract: Photodynamic therapy (PDT) and photodynamic diagnosis of cancer are widely used in clinical fields. These are performed using photosensitizers. Many metalloporphyrin-related compounds have been developed as photosensitizers for use in PDT, and these tumor localization ability have been improved in recent research. Moreover, the precursor of porphyrin 5-aminolevulinic acid is used in fluorescence diagnosis using its tumor localization ability. In this review, these applications of photosensitizers in cancer therapy and diagnosis are summarized.

Cite this article as:

Ogura Shun-Ichiro, Hagiya Yuichiro, Tabata Kenji, Kamachi Toshiaki and Okura Ichiro, Improvement of Tumor Localization of Photosensitizers for Photodynamic Therapy and Its Application for Tumor Diagnosis, Current Topics in Medicinal Chemistry 2012; 12 (3) . https://dx.doi.org/10.2174/156802612799078883