Abstract
Opioid peptides showing selectivity for d receptor have been isolated from enzymatic digests of plant proteins. Five peptides were derived from wheat gluten, and named gluten exorphins A5, A4, B5, B4 and C. Two opioid peptides were also released from spinach ribulosebisphosphate- carboxylase / oxygenase (Rubisco), and named rubiscolins-5 and -6. Among them, gluten exorphin 5A (Gly-Tyr-Tyr-Pro-Thr) and rubiscolin-6 (Tyr-Pro-Leu-Asp-Leu-Phe) improved learning performance in step-through type passive avoidance test after post-training oral administration in mice at doses of 300 mg / kg and 100 mg / kg, respectively, which are smaller than those required for antinociceptive activity.
Keywords: opioid peptide, gluten exorphin, rubisco, antinociception, learning, memory, anxiolytic, antidepressant
Current Pharmaceutical Design
Title: Delta Opioid Peptides Derived from Plant Proteins
Volume: 9 Issue: 16
Author(s): M. Yoshikawa, M. Takahashi and S. Yang
Affiliation:
Keywords: opioid peptide, gluten exorphin, rubisco, antinociception, learning, memory, anxiolytic, antidepressant
Abstract: Opioid peptides showing selectivity for d receptor have been isolated from enzymatic digests of plant proteins. Five peptides were derived from wheat gluten, and named gluten exorphins A5, A4, B5, B4 and C. Two opioid peptides were also released from spinach ribulosebisphosphate- carboxylase / oxygenase (Rubisco), and named rubiscolins-5 and -6. Among them, gluten exorphin 5A (Gly-Tyr-Tyr-Pro-Thr) and rubiscolin-6 (Tyr-Pro-Leu-Asp-Leu-Phe) improved learning performance in step-through type passive avoidance test after post-training oral administration in mice at doses of 300 mg / kg and 100 mg / kg, respectively, which are smaller than those required for antinociceptive activity.
Export Options
About this article
Cite this article as:
Yoshikawa M., Takahashi M. and Yang S., Delta Opioid Peptides Derived from Plant Proteins, Current Pharmaceutical Design 2003; 9 (16) . https://dx.doi.org/10.2174/1381612033454838
DOI https://dx.doi.org/10.2174/1381612033454838 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Borderland and Borderline: Understanding and Treating Adolescent Migrants in Crisis
Adolescent Psychiatry Review of Antibiotic and Non-Antibiotic Properties of Beta-lactam Molecules
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Therapy of Acute Hepatitis C: A Review of Literature
Current Pharmaceutical Design Structure, Functions and Selective Inhibitors of HDAC6
Current Topics in Medicinal Chemistry The Hyperforin Derivative IDN5706 Occludes Spatial Memory Impairments and Neuropathological Changes in a Double Transgenic Alzheimers Mouse Model
Current Alzheimer Research Effect of Electromagnetic Radiations on Neurodegenerative Diseases- Technological Revolution as a Curse in Disguise
CNS & Neurological Disorders - Drug Targets The “Aged Garlic Extract” (AGE) and One of its Active Ingredients S-Allyl-LCysteine (SAC) as Potential Preventive and Therapeutic Agents for Alzheimer's Disease (AD)
Current Medicinal Chemistry PEGylated Dendritic Architecture for Development of a Prolonged Drug Delivery System for an Antitubercular Drug
Current Drug Delivery Enhanced Detection of Characteristic Vibration Signal of Generator Based on Self-Adapted Multi-Scale Top-Hat Transformation
Recent Advances in Electrical & Electronic Engineering Synthesis and Biological Evaluation of Triazole-Vanillin Molecular Hybrids as Anti-Cancer Agents
Current Bioactive Compounds Pain and Opioid Addiction: A Systematic Review and Evaluation of Pain Measurement in Patients with Opioid Dependence on Methadone Maintenance Treatment
Current Drug Abuse Reviews Antioxidative Properties of Flavonoids
Current Organic Chemistry Carbon Monoxide - Toxicity of Low-Dose Application
Current Pharmaceutical Biotechnology Proceeding of the 8th Alcohol Hangover Research Group Meeting
Current Drug Abuse Reviews High Sensitivity C-Reactive Protein (hsCRP): A New Biochemical Marker of Atherosclerotic Vascular Disease
Current Cardiology Reviews Opening New Scenarios for Human MAO Inhibitors
Central Nervous System Agents in Medicinal Chemistry Blood Brain Barrier in Hypoxic-Ischemic Conditions
Current Neurovascular Research Perfusion MRI of Brain Neoplams
Current Medical Imaging Dipyridamole: A Drug with Unrecognized Antioxidant Activity
Current Topics in Medicinal Chemistry The Neuropsychological Hypothesis of Antidepressant Drug Action Revisited
CNS & Neurological Disorders - Drug Targets