Polyene Macrolide Antibiotic Biosynthesis

Title: Polyene Macrolide Antibiotic Biosynthesis

Volume: 11 Issue: 12

Author(s): J. F. Aparicio, M. V. Mendes, N. Anton, E. Recio and J. F. Martin

Affiliation:

Keywords: polyene, polyketide synthase, macrolide, antifungal

Abstract: Polyenes constitute a large class of natural metabolites produced by giant multifunctional enzymes in a process resembling fatty acid biosynthesis. Like fatty acids, polyene macrolides and other polyketides are assembled by decarboxylative condensations of simple carboxylic acids. But while fatty acid intermediates are fully reduced, polyene macrolide intermediates suffer the suppression of reduction or dehydration reactions at given biosynthetic steps. In the last years, much progress has been made in our understanding of the linear and modular organization of the gene clusters, and the enzymes encoded by them, responsible for the biosynthesis of these macrocyclic metabolites. This know-how about the rules that govern polyene chain growth has provided the basis for the first rational manipulations of these fascinating systems for the production of engineered derivatives and promises a new era of novel polyene development, which will hopefully yield new molecules with improved pharmacological properties.

Cite this article as:

Aparicio F. J., Mendes V. M., Anton N., Recio E. and Martin F. J., Polyene Macrolide Antibiotic Biosynthesis, Current Medicinal Chemistry 2004; 11 (12) . https://dx.doi.org/10.2174/0929867043365044