Harnessing the Capacity of Cell-Penetrating Peptides for Drug Delivery to the Central Nervous System

Title:Harnessing the Capacity of Cell-Penetrating Peptides for Drug Delivery to the Central Nervous System

Volume: 15 Issue: 3

Author(s): Ting Kang, Xiaoling Gao and Jun Chen

Affiliation:

Keywords: Blood-brain barrier, cell penetrating peptides, central nervous system, drug delivery.

Abstract: The existence of blood-brain barrier (BBB) represents the most formidable challenge for drug delivery to the central nervous system (CNS). Modern breakthrough in biology offers multiple choices for overcoming this barrier but yields modest outcomes for clinical application due to various problems such as safety concerns, insufficient delivery efficiency and poor penetration. Cell penetrating peptides (CPPs) possessing powerful transmembrane capacity have been shown to be effective transport vectors for bioactive molecules and an attractive alternative to traditional active targeting approaches. However, the non-specificity of CPPs has hindered them from targeting a desired site of action. Promisingly, design of novel CPP-mediated nanoparticulate delivery systems with specific targeting property may extricate CPPs from the dilemma. In this review, both the traditional and novel applications of CPPs-based strategies for CNS drug delivery will be discussed.

Cite this article as:

Kang Ting, Gao Xiaoling and Chen Jun, Harnessing the Capacity of Cell-Penetrating Peptides for Drug Delivery to the Central Nervous System, Current Pharmaceutical Biotechnology 2014; 15 (3) . https://dx.doi.org/10.2174/1389201015666140617094952