Environmentally Friendly Suzuki Aryl-Aryl Cross-Coupling Reaction

L.      Bai; J.-   X.   Wang

doi:10.2174/1385272053544407

Abstract

Suzuki coupling is probably the most versatile approach among the cross-coupling reactions and the reaction has long been the subject of intensive work in the area of transition-metal chemistry. From both scientific and environmental points of view, various modifications have recently been developed that the Suzuki reactions involve catalysts, substrates, reaction media, reaction conditions and synthetic techniques. This review will focus on describing both the seminal early work and the exciting recent development in the area of the environmentally friendly Suzuki arylaryl coupling reaction. Transformations that will be covered include the use of green media such as water, ethanol, poly(ethylene glycol), supercritical carbon dioxide, ionic liquids and solvent-free etc.; the design of recoverable and reusable polymer-supported catalysts and entrapment or intercalation of metal species; and the development of synthetic methodology involving ultrasound irradiation and microwave heating technique.

Keywords: palladium-catalyzed cross-coupling reaction, suzuki coupling, organometallic reagents, catalysts, tetrabutylammonium bromide (tbab), cyclodextrin, polymerization, cetyltrimethylammonium bromide (ctab)