Recent Progress in Discovery and Development of Antimitotic Agents

Title: Recent Progress in Discovery and Development of Antimitotic Agents

Volume: 7 Issue: 2

Author(s): Alex Kiselyov, Konstantin V. Balakin, Sergey E. Tkachenko, Nikolay Savchuk and Alexandre V. Ivachtchenko

Affiliation:

Keywords: antimitotic agent, inhibitor of tubulin polymerization, microtubule-stabilizing agent, mitotic kinesin, mitotic kinase

Abstract: This review highlights structural diversity of antimitotic agents. In particular, we emphasized current antimitotic therapies based on modulation of microtubule dynamics. With several successful anticancer drugs on the market and numerous compounds in clinical developments, tubulin-binding agents remain among the most important categories of anticancer agents. Compounds targeting mitotic kinases and kinesins are also discussed.

Cite this article as:

Kiselyov Alex, Balakin V. Konstantin, Tkachenko E. Sergey, Savchuk Nikolay and Ivachtchenko V. Alexandre, Recent Progress in Discovery and Development of Antimitotic Agents, Anti-Cancer Agents in Medicinal Chemistry 2007; 7 (2) . https://dx.doi.org/10.2174/187152007780058650