Abstract
Potassium channels form highly K+ ion-selective pores in the plasma membrane of excitable cells. Voltagegated potassium (Kv) channels open in response to membrane depolarization to allow rapid diffusion of K+ ions out of the cell, thus repolarizing the cell to restore a negative resting membrane potential. Inherited mutations in Kv channel genes produce abnormal cellular repolarization and cause diseases of excitable tissues. Small molecule interactions with Kv channels can cause similar pathologies. During the last decade of research into Kv channels and associated diseases - termed ‘channelopathies’ - we have begun to understand Kv channel function and dysfunction at the molecular level. In this review, the molecular mechanisms of Kv channelopathies are discussed, with particular emphasis on the overlap between inherited and acquired disease, and the drive towards novel channel-targeted therapies.
Keywords: Arrhythmia, hERG, IKr, IKs, KCNE, KCNQ1, Kv1.5, MinK, MiRP1
Current Pharmaceutical Design
Title: Molecular Mechanisms of Cardiac Voltage-Gated Potassium Channelopathies
Volume: 12 Issue: 28
Author(s): Geoffrey W. Abbott
Affiliation:
Keywords: Arrhythmia, hERG, IKr, IKs, KCNE, KCNQ1, Kv1.5, MinK, MiRP1
Abstract: Potassium channels form highly K+ ion-selective pores in the plasma membrane of excitable cells. Voltagegated potassium (Kv) channels open in response to membrane depolarization to allow rapid diffusion of K+ ions out of the cell, thus repolarizing the cell to restore a negative resting membrane potential. Inherited mutations in Kv channel genes produce abnormal cellular repolarization and cause diseases of excitable tissues. Small molecule interactions with Kv channels can cause similar pathologies. During the last decade of research into Kv channels and associated diseases - termed ‘channelopathies’ - we have begun to understand Kv channel function and dysfunction at the molecular level. In this review, the molecular mechanisms of Kv channelopathies are discussed, with particular emphasis on the overlap between inherited and acquired disease, and the drive towards novel channel-targeted therapies.
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Cite this article as:
Abbott W. Geoffrey, Molecular Mechanisms of Cardiac Voltage-Gated Potassium Channelopathies, Current Pharmaceutical Design 2006; 12 (28) . https://dx.doi.org/10.2174/138161206778522065
DOI https://dx.doi.org/10.2174/138161206778522065 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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