Search Result "IKr"


The Impact of IKr Blockade on Medicinal Chemistry Programs

Journal: Current Topics in Medicinal Chemistry
Volume: 8 Issue: 1 Year: 2008 Page: 1128-1139
Author(s): Ian M. Bell, Mark T. Bilodeau

New Proposals for Testing Drugs with IKr-Blocking Activity to Determine Their Teratogenic Potential

Journal: Current Pharmaceutical Design
Volume: 13 Issue: 2 Year: 2007 Page: 2979-2988
Author(s): Miriam Karlsson, Bengt R. Danielsson, Mats F. Nilsson, Christian Danielsson, William S. Webster

The Cardiac hERG/IKr Potassium Channel as Pharmacological Target: Structure, Function, Regulation, and Clinical Applications

Journal: Current Pharmaceutical Design
Volume: 12 Issue: 1 Year: 2006 Page: 2271-2283
Author(s): D. Thomas, C. A. Karle, J. Kiehn

Enhanced Repolarization Capacity: New Potential Antiarrhythmic Strategy Based on hERG Channel Activation

Journal: Current Medicinal Chemistry
Volume: 18 Issue: 2 Year: 2011 Page: 3607-3621
Author(s): G. Szabo, V. Farkas, M. Grunnet, A. Mohacsi, P. P. Nanasi

Drug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias

Journal: Current Cardiology Reviews
Volume: 12 Issue: 2 Year: 2016 Page: 141-154
Author(s): Luigi X. Cubeddu

The hERG Channel and Risk of Drug-Acquired Cardiac Arrhythmia: An Overview

Journal: Current Topics in Medicinal Chemistry
Volume: 8 Issue: 1 Year: 2008 Page: 1102-1112
Author(s): Armando A. Lagrutta, Elena S. Trepakova, Joseph J. Salata

Effect of the Antifibrillatory Compound Tedisamil (KC-8857) on Transmembrane Currents in Mammalian Ventricular Myocytes

Journal: Current Medicinal Chemistry
Volume: 11 Issue: 2 Year: 2004 Page: 3219-3228
Author(s): N. Jost, L. Virag, O. Hala, A. Varro, D. Thormahlen, J. Gy. Papp

Drug Induced QT Prolongation: Lessons from Congenital and Acquired Long QT Syndromes

Journal: Current Drug Targets - Cardiovascular & Hematological Disorders
Volume: 3 Issue: 4 Year: 2003 Page: 327-335
Author(s): Bruce D. Walker, Andrew D. Krahn, George J. Klein, Allan C. Skanes, Raymond Yee

Molecular Predictors of Drug-induced Prolongation of the QT Interval

Journal: Current Medicinal Chemistry - Cardiovascular & Hematological Agents
Volume: 3 Issue: 2 Year: 2005 Page: 105-118
Author(s): Polychronis E. Dilaveris, Christodoulos I. Stefanadis

Mechanisms of Drug Induced QT Interval Prolongation

Journal: Current Drug Safety
Volume: 5 Issue: 1 Year: 2010 Page: 44-53
Author(s): Marcelo Luis Ponte, Guillermo Alberto Keller, Guillermo Di Girolamo

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