Abstract
Kainic acid and related members of kainoid family are amino acid-terpene hybrid natural products with three stereocenters and promising bioactivities. Kainoids have been isolated from diverse marine and terrestrial organisms and all of them feature a 3-carboxymethyl proline and C-4 side chain. The decorative molecular structure and intriguing biological profile of kainic acid inspired the synthetic chemists in engineering the new protocol for its asymmetric total syntheses. This article provides an account of research on kainic acid and few selective kainic acid inspired molecules, including their isolation, total synthesis, biological and structure activity relationship (SAR) studies. Particularly, the synthetic endeavours towards the building of kainic acid reported during the period 2012 till mid 2015 have been highlighted.
Keywords: Marine metabolites, synthesis, bioactivities, kainic acid, hybrid natural product.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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