4'-Thionucleosides as Potent and Selective A₃ Adenosine Receptor Ligands

Title:4'-Thionucleosides as Potent and Selective A₃ Adenosine Receptor Ligands

Volume: 20 Issue: 8

Author(s): Pramod K. Sahu, Siddhi D. Naik, Sofia Mehdi and Lak S. Jeong

Affiliation:

Keywords: A₃ adenosine receptor, agonist, antagonist, 4’-thionucleoside, structure-activity relationship.

Abstract: A₃ adenosine receptors (ARs) have long been viewed as potential therapeutic targets due to their association with a variety of pathophysiological processes. Development of potent and selective A₃AR nucleoside ligands has been an area of interest of medicinal chemists since last two decades. Various prime modifications made on N6 and C-2 position of the adenosine moiety has led to the discovery of some of the most efficacious A₃AR ligands. This review is an account of the development of 4'-thionucleosides as A₃AR agonists and antagonists by various chemical modifications on the thionucleoside template.

Cite this article as:

K. Sahu Pramod, D. Naik Siddhi, Mehdi Sofia and S. Jeong Lak, 4'-Thionucleosides as Potent and Selective A₃ Adenosine Receptor Ligands, Current Organic Chemistry 2016; 20 (8) . https://dx.doi.org/10.2174/1385272819666150804000511