Abstract
Kainic acid and related members of kainoid family are amino acid-terpene hybrid natural products with three stereocenters and promising bioactivities. Kainoids have been isolated from diverse marine and terrestrial organisms and all of them feature a 3-carboxymethyl proline and C-4 side chain. The decorative molecular structure and intriguing biological profile of kainic acid inspired the synthetic chemists in engineering the new protocol for its asymmetric total syntheses. This article provides an account of research on kainic acid and few selective kainic acid inspired molecules, including their isolation, total synthesis, biological and structure activity relationship (SAR) studies. Particularly, the synthetic endeavours towards the building of kainic acid reported during the period 2012 till mid 2015 have been highlighted.
Keywords: Marine metabolites, synthesis, bioactivities, kainic acid, hybrid natural product.
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Current Organic Chemistry
Title:Recent Progress in Syntheses and Biological Activities of Kainic Acid and its Derivatives
Volume: 20 Issue: 8
Author(s): Mahesh S. Majik and Vinod K. Mandrekar
Affiliation:
Keywords: Marine metabolites, synthesis, bioactivities, kainic acid, hybrid natural product.
Abstract: Kainic acid and related members of kainoid family are amino acid-terpene hybrid natural products with three stereocenters and promising bioactivities. Kainoids have been isolated from diverse marine and terrestrial organisms and all of them feature a 3-carboxymethyl proline and C-4 side chain. The decorative molecular structure and intriguing biological profile of kainic acid inspired the synthetic chemists in engineering the new protocol for its asymmetric total syntheses. This article provides an account of research on kainic acid and few selective kainic acid inspired molecules, including their isolation, total synthesis, biological and structure activity relationship (SAR) studies. Particularly, the synthetic endeavours towards the building of kainic acid reported during the period 2012 till mid 2015 have been highlighted.
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Cite this article as:
S. Majik Mahesh and K. Mandrekar Vinod, Recent Progress in Syntheses and Biological Activities of Kainic Acid and its Derivatives, Current Organic Chemistry 2016; 20 (8) . https://dx.doi.org/10.2174/1385272819666150804000728
DOI https://dx.doi.org/10.2174/1385272819666150804000728 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
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The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
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