Abstract
Numerous reports indicate that lipid or protein associated carbohydrates are essential for infection of cells by various viruses, bacteria, or bacterial toxins, some of which affect the nervous system. Examples of such pathogens include tetanus and botulinum neurotoxin, Shiga and Shiga-like toxins, Borrelia burgdorferi, Mycobacterium leprae, and human immunodeficiency virus. This review discusses evidence indicating that carbohydrates are essential for these pathogens to induce their deleterious effects, the putative function of the carbohydrates, and how this knowledge might be used to combat the effects of the pathogen.
Keywords: Botulinum toxin, tetanus toxin, Lyme disease, leprosy, HIV, glycosphingolipids, multivalent carbohydrate ligands, carbohydrate antigens
CNS & Neurological Disorders - Drug Targets
Title: Glycoconjugates: Roles in Neural Diseases Caused by Exogenous Pathogens
Volume: 5 Issue: 4
Author(s): Cara-Lynne Schengrund
Affiliation:
Keywords: Botulinum toxin, tetanus toxin, Lyme disease, leprosy, HIV, glycosphingolipids, multivalent carbohydrate ligands, carbohydrate antigens
Abstract: Numerous reports indicate that lipid or protein associated carbohydrates are essential for infection of cells by various viruses, bacteria, or bacterial toxins, some of which affect the nervous system. Examples of such pathogens include tetanus and botulinum neurotoxin, Shiga and Shiga-like toxins, Borrelia burgdorferi, Mycobacterium leprae, and human immunodeficiency virus. This review discusses evidence indicating that carbohydrates are essential for these pathogens to induce their deleterious effects, the putative function of the carbohydrates, and how this knowledge might be used to combat the effects of the pathogen.
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Cite this article as:
Schengrund Cara-Lynne, Glycoconjugates: Roles in Neural Diseases Caused by Exogenous Pathogens, CNS & Neurological Disorders - Drug Targets 2006; 5 (4) . https://dx.doi.org/10.2174/187152706777950701
DOI https://dx.doi.org/10.2174/187152706777950701 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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