Abstract
Interactions between cyclosporin A and three silymarin flavonoids (silybin, silydianin, and silychristin) were studied on the rat hepatocyte plasma membrane using the replacement of [3H]cyclosporin A by silymarin flavonoids. It was found that flavonoids significantly replaced CsA from its binding to the rat hepatocyte plasma membrane. It seems that these two types of compounds are competitors at the same binding site of the plasma membrane receptor.
Keywords: Cyclosporin A, silymarin flavonoids, hepatocytes, membrane transport
Letters in Drug Design & Discovery
Title: Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids
Volume: 3 Issue: 6
Author(s): Vladimira Moulisova, Jiri Sebestian, Olga Jedlickova, Alexandr Jegorov and Stepanka B. Sebestianova
Affiliation:
Keywords: Cyclosporin A, silymarin flavonoids, hepatocytes, membrane transport
Abstract: Interactions between cyclosporin A and three silymarin flavonoids (silybin, silydianin, and silychristin) were studied on the rat hepatocyte plasma membrane using the replacement of [3H]cyclosporin A by silymarin flavonoids. It was found that flavonoids significantly replaced CsA from its binding to the rat hepatocyte plasma membrane. It seems that these two types of compounds are competitors at the same binding site of the plasma membrane receptor.
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Cite this article as:
Moulisova Vladimira, Sebestian Jiri, Jedlickova Olga, Jegorov Alexandr and Sebestianova B. Stepanka, Replacement of Cyclosporin A from its Binding to Hepatocyte Plasma Membrane by Silymarin Flavonoids, Letters in Drug Design & Discovery 2006; 3 (6) . https://dx.doi.org/10.2174/157018006777805567
DOI https://dx.doi.org/10.2174/157018006777805567 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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