Function and Molecular Mechanism of Tumor-Targeted Peptides for Delivering Therapeutic Genes and Chemical Drugs

Ryan      Craig; Shulin      Li

doi:10.2174/138955706777698615

Abstract

Tumor-targeted chemo- or gene-therapies is a new form of treatment which provides the benefits ofreducing systemic toxicity, increasing the tolerance, and enhancing therapeutic efficacy. This review willdiscuss the discovery, function, application, and mechanism by which the short peptides (5-9) work for tumor-targeted gene or drug delivery.

Keywords: Peptide, tumor-targeting, tumor vessel, gene therapy, gene delivery, drug delivery, adhesion molecule, phage display