The Synthesis and Use of Boronated Amino Acids for Boron Neutron Capture Therapy

Title: The Synthesis and Use of Boronated Amino Acids for Boron Neutron Capture Therapy

Volume: 6 Issue: 2

Author(s): George W. Kabalka and Min-Liang Yao

Affiliation:

Keywords: isotopes, linear energy transfer (LET), 4-Dihydroxyborylphenylalanine, water-solubilizing functional group, melanoma, Bucherer-Strecker reaction

Abstract: The treatment of cancer remains one of the most challenging problems for humanity. Boron neutron capture therapy (BNCT) is a binary approach for cancer treatment that is particularly attractive in treating high-grade gliomas and metastatic brain tumors. Among types of boron-containing molecules used as BNCT agents, boronated amino acids have received significant attention for their preferentially uptake by growing tumor cells. This review emphasizes the synthesis of boronated amino acids.

Cite this article as:

Kabalka W. George and Yao Min-Liang, The Synthesis and Use of Boronated Amino Acids for Boron Neutron Capture Therapy, Anti-Cancer Agents in Medicinal Chemistry 2006; 6 (2) . https://dx.doi.org/10.2174/187152006776119144