Necrotizing Enterocolitis: Clinical Features, Histopathological Characteristics,
and Genetic Associations

Akhil      Maheshwari; Terri   M.   Traub; Parvesh   M.   Garg; Yahya      Ethawi; Giuseppe      Buonocore
doi:10.2174/1573396318666220204113858
Abstract

Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis seen in premature infants. Although the etiopathogenesis of NEC is unclear, genetic factors may alter a patient's susceptibility, clinical course, and outcomes. This review draws from existing studies focused on individual genes and others based on microarray-based high-throughput discovery techniques. We have included evidence from our own studies and from an extensive literature search in the databases PubMed, EMBASE, and Scopus. To avoid bias in the identification of studies, keywords were short-listed a priori from anecdotal experience and PubMed’s Medical Subject Heading (MeSH) thesaurus.
Keywords: Necrotizing enterocolitis, clinical, histopathology, genetic, genomic, microarray, necrosis.
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DOI https://dx.doi.org/10.2174/1573396318666220204113858	Print ISSN 1573-3963
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Necrotizing Enterocolitis: Clinical Features, Histopathological Characteristics, and Genetic Associations

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