Abstract
Background: Although imaging findings along with patients’ clinical history may give a clue for the etiology of a pulmonary lesion, the differentiation of benign pulmonary lesions from lung cancer could be challenging.
Objective: The aim of this review article was to increase the awareness of carcinoma mimicking lung lesions.
Methods: This paper was designed to illustrate rare pulmonary tumors and carcinoma mimickers with emphasis on radiologic-pathologic correlation. Pitfalls encountered on CT images and also false positivity of PET-CT scans were also presented.
Conclusion: Several benign pulmonary lesions may grow in size on follow-up and some may show pathologic FDG (18F-fluorodeoxyglucose) uptake, which makes them indistinguishable from lung carcinoma by imaging. In addition, some slow-growing malignant lesions, such as carcinoid, may be false-negative on PET/CT scans.
Keywords: Lung cancer, CT, benign pulmonary tumors, percutaneous transthoracic biopsy, MRI, PET/CT scan.
Graphical Abstract
[http://dx.doi.org/10.2214/AJR.08.1837] [PMID: 19234263]
[http://dx.doi.org/10.2214/AJR.10.7262] [PMID: 22997395]
[http://dx.doi.org/10.1148/radiographics.22.3.g02ma25601] [PMID: 12006690]
[PMID: 23680478]
[http://dx.doi.org/10.1097/RLU.0b013e31820aa00c] [PMID: 21467848]
[http://dx.doi.org/10.1097/JTO.0b013e31819d4778] [PMID: 19395909]
[http://dx.doi.org/10.1111/crj.12280] [PMID: 25689088]
[http://dx.doi.org/10.2478/v10019-012-0004-4] [PMID: 22933975]
[http://dx.doi.org/10.1007/s003300050082] [PMID: 10757002]
[http://dx.doi.org/10.1148/radiology.160.2.3726106] [PMID: 3726106]
[http://dx.doi.org/10.1016/S0009-9260(65)80033-2] [PMID: 14249223]
[http://dx.doi.org/10.2214/AJR.11.8056] [PMID: 22915423]
[http://dx.doi.org/10.1097/RCT.0b013e31815abed4] [PMID: 19204455]
[http://dx.doi.org/10.3892/ol.2018.8660] [PMID: 29930720]
[http://dx.doi.org/10.1097/MD.0000000000000498] [PMID: 25634202]
[http://dx.doi.org/10.1097/00004728-199401000-00007] [PMID: 8282879]
[http://dx.doi.org/10.1016/j.crad.2011.03.002] [PMID: 21529795]
[http://dx.doi.org/10.3904/kjim.2007.22.2.122] [PMID: 17616030]
[PMID: 9677459]
[http://dx.doi.org/10.1183/09031936.02.00404102] [PMID: 12358356]
[http://dx.doi.org/10.1148/rg.2016140339] [PMID: 26761531]
[http://dx.doi.org/10.2214/ajr.168.1.8976927] [PMID: 8976927]
[http://dx.doi.org/10.2214/ajr.172.5.10227510] [PMID: 10227510]
[http://dx.doi.org/10.3348/kjr.2000.1.3.159] [PMID: 11752947]
[http://dx.doi.org/10.1148/rg.301095088] [PMID: 20083598]
[http://dx.doi.org/10.1111/j.1600-0609.2007.00895.x] [PMID: 17662066]
[http://dx.doi.org/10.1148/rg.261055070] [PMID: 16418244]
[PMID: 25852756]
[http://dx.doi.org/10.2214/ajr.174.2.1740523] [PMID: 10658734]
[http://dx.doi.org/10.1097/RLU.0b013e31821a2978] [PMID: 21892061]
[http://dx.doi.org/10.1007/s003300050446] [PMID: 9569334]
[http://dx.doi.org/10.1177/0284185117700929] [PMID: 28361545]
[http://dx.doi.org/10.1148/rg.261055057] [PMID: 16418242]
[http://dx.doi.org/10.1002/cncr.11105] [PMID: 12569593]
[http://dx.doi.org/10.1148/radiology.179.2.2014296] [PMID: 2014296]
[http://dx.doi.org/10.2214/ajr.170.5.9574618] [PMID: 9574618]
[http://dx.doi.org/10.1097/00003072-200411000-00026] [PMID: 15483502]
[http://dx.doi.org/10.2214/AJR.09.3940] [PMID: 20858818]
[http://dx.doi.org/10.2214/ajr.170.2.9456931] [PMID: 9456931]
[http://dx.doi.org/10.4274/mirt.03016] [PMID: 26316470]
[http://dx.doi.org/10.1007/s00259-006-0073-y] [PMID: 16568202]
[http://dx.doi.org/10.1148/rg.321115060] [PMID: 22236893]
[http://dx.doi.org/10.1097/00004728-199111000-00008] [PMID: 1939773]
[http://dx.doi.org/10.1007/s00330-002-1422-2] [PMID: 12541109]
[http://dx.doi.org/10.1007/s12149-012-0675-3] [PMID: 23242952]
[http://dx.doi.org/10.1007/s12149-013-0769-6] [PMID: 24037685]
[http://dx.doi.org/10.4329/wjr.v8.i6.581] [PMID: 27358685]
[http://dx.doi.org/10.1148/radiographics.20.3.g00ma06795] [PMID: 10835129]
[http://dx.doi.org/10.1148/rg.232025704] [PMID: 12640161]
[http://dx.doi.org/10.1016/j.actatropica.2009.11.001] [PMID: 19931502]
[http://dx.doi.org/10.1183/09031936.03.00108403] [PMID: 12797504]
[http://dx.doi.org/10.1136/bcr.11.2010.3539]
[http://dx.doi.org/10.4103/2348-3334.158722]
[http://dx.doi.org/10.1148/rg.285075212] [PMID: 18794313]
[http://dx.doi.org/10.1148/radiol.10092129] [PMID: 21183492]