The Role of Flavonoids in Inhibiting IL-6 and Inflammatory Arthritis

Ayman   M.   Mahmoud; Ahmed   M.   Sayed; Osama   S.   Ahmed; Mohamed   M.   Abdel-Daim; Emad   H.M.   Hassanein
doi:10.2174/1568026622666220107105233
Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the synovial joints. RA has well-known clinical manifestations and can cause progressive disability and premature death along with socioeconomic burdens. Interleukin-6 (IL-6) has been implicated in the pathology of RA where it can stimulate pannus formation, osteoclastogenesis, and oxidative stress. Flavonoids are plant metabolites with beneficial pharmacological effects, including anti-inflammatory, antioxidant, antidiabetic, anticancer, etc. Flavonoids are polyphenolic compounds found in a variety of plants, vegetables, and fruits. Many flavonoids have demonstrated anti-arthritic activity mediated mainly through the suppression of pro-inflammatory cytokines. This review thoroughly discusses the accumulated data on the role of flavonoids on IL-6 in RA.
Keywords: Rheumatoid arthritis, Inflammation, Flavonoids, Cytokines, IL-6, Polyphenols.
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DOI https://dx.doi.org/10.2174/1568026622666220107105233	Print ISSN 1568-0266
Publisher Name Bentham Science Publisher	Online ISSN 1873-4294
Current Topics in Medicinal Chemistry

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