Abstract
Ephedra compounds are well known due to their biological activity. They have been widely used in asymmetric synthesis during the last decades. To our knowledge no review about acyclic ephedra derivative compounds has appeared in the literature. In this paper, the synthetic methodologies to access ephedrines and chiral compounds derived from them are summarized, including those by substitution of the hydroxy group by chlorine, sulfur, nitrogen or phosphorous containing groups. Ephedrines and some ephedra derivatives have displayed biological activity. Some of them have been used as asymmetric inductor ligands or catalysts in asymmetric synthesis. Clearly the ephedra derivatives are potential candidates to be used in both areas.
Keywords: Ephedrines, Biological Activity, Chirality, Configuration, Stereoespecificity, Asymmetric Synthesis, Acyclic Derivatives, NOREPHEDRINES
Current Organic Synthesis
Title: Ephedrines and their Acyclic Derivatives
Volume: 8 Issue: 6
Author(s): Alejandro Cruz and Maria Esther Bautista Ramirez
Affiliation:
Keywords: Ephedrines, Biological Activity, Chirality, Configuration, Stereoespecificity, Asymmetric Synthesis, Acyclic Derivatives, NOREPHEDRINES
Abstract: Ephedra compounds are well known due to their biological activity. They have been widely used in asymmetric synthesis during the last decades. To our knowledge no review about acyclic ephedra derivative compounds has appeared in the literature. In this paper, the synthetic methodologies to access ephedrines and chiral compounds derived from them are summarized, including those by substitution of the hydroxy group by chlorine, sulfur, nitrogen or phosphorous containing groups. Ephedrines and some ephedra derivatives have displayed biological activity. Some of them have been used as asymmetric inductor ligands or catalysts in asymmetric synthesis. Clearly the ephedra derivatives are potential candidates to be used in both areas.
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Cite this article as:
Cruz Alejandro and Esther Bautista Ramirez Maria, Ephedrines and their Acyclic Derivatives, Current Organic Synthesis 2011; 8 (6) . https://dx.doi.org/10.2174/1570179411108060901
DOI https://dx.doi.org/10.2174/1570179411108060901 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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