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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Mini-Review Article

Effects of Flavonoids in Experimental Models of Arterial Hypertension

Author(s): Noemi M. Atucha*, Paola Romecín, Felix Vargas and Joaquin García-Estañ*

Volume 22, Issue 9, 2022

Published on: 08 December, 2021

Page: [735 - 745] Pages: 11

DOI: 10.2174/1568026621666211105100800

Price: $65

Abstract

Flavonoids are a class of substances of a vegetal origin with many interesting actions from the point of view of human disease. Interest in flavonoids in the diet has increased in recent years due to the publication of basic, clinical and epidemiological studies that have shown a whole array of salutary effects related to intake of flavonols and flavones as well as a lower morbility and mortality of cardiovascular diseases. Since arterial hypertension is the most common modifiable risk factor for cardiovascular diseases, this review will focus mainly on the effects of flavonoids on the cardiovascular system with relation to the elevation of blood pressure. Its antihypertensive effects as well as the many investigations performed in experimental models of arterial hypertension, are reviewed in this mini-review.

Keywords: Endothelium, Oxidative stress, Hypertension, Renal, Nitric Oxide, Quercetin, Apigenin, Hesperidin.

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