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Current Cardiology Reviews

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ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

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Perspective

An Update on New Cholesterol Inhibitor: Bempedoic Acid

Author(s): Mayank Kulshreshtha*

Volume 18, Issue 2, 2022

Published on: 13 January, 2022

Article ID: e141221198875 Pages: 4

DOI: 10.2174/1573403X17666211214111658

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Abstract

An increase in the level of cholesterol day by day is easily seen in most people just because of poor life style, food with high cholesterol, lack of physical work, etc. There are lots of molecules available, which lower down the cholesterol level. In this field a new molecule has been introduced that is bimpedoic acid. Researches indicate that bempedoic acid has the same mechanism of action as statins, which means that it also inhibits the HMG-CoA reductase enzyme. This article is my best collection of published scientific data on bempedoic acid till now. It also includes the chemistry, pharmacodynamic and pharmacokinetic parameters of the mentioned new molecule.

Keywords: Cholesterol, bempedoic acid, HMG-CoA reductase enzyme, lipoproteins, gastrointestinal, hypoglycemic activity.

Graphical Abstract

[1]
World Health Organization. Cardiovascular diseases. Available from: https://www.who.int/health- topics/cardiovascular-diseases/#tab=tab_1 (Accessed on Feb 15, 2021).
[2]
Zhao D, Liu J, Wang M, Zhang X, Zhou M. Epidemiology of cardiovascular disease in China: current features and implications. Nat Rev Cardiol 2019; 16(4): 203-12.
[http://dx.doi.org/10.1038/s41569-018-0119-4] [PMID: 30467329]
[3]
Benjamin EJ, Muntner P, Alonso A, et al. Heart disease and stroke statistics-2019 update: A report from the American heart association. Circulation 2019; 139(10): e56-e528.
[http://dx.doi.org/10.1161/CIR.0000000000000659] [PMID: 30700139]
[4]
Nexletol- Bempedoic Acid Tablet, Film Coated. Daily Med. Available from: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=88d06d89-a3da-40b4-b273-8f4f7d56c4c9 (Accessed on Feb 15, 2021).
[5]
Nexletol: FDA-Approved drugs. US Food and Drug Administration (FDA) 2020. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/211616Orig1s000TOC.cfm (Accessed on Feb 15, 2021).
[6]
Ray KK, Bays HE, Catapano AL, et al. Safety and efficacy of bempedoic acid to reduce LDL cholesterol. N Engl J Med 2019; 380(11): 1022-32.
[http://dx.doi.org/10.1056/NEJMoa1803917] [PMID: 30865796]
[7]
Bempedoic acid. Esperion Therapeutics. Available from: https://adisinsight.springer.com/drugs/800031255 (Accessed on Feb 15, 2021).
[8]
European Medicines Agencey. Nustendi. Available from: https://www.ema.europa.eu/en/medicines/human/summaries-opinion/nustendi (Accessed on Feb 15, 2021).
[9]
Lipids. Available from: https://www.britannica.com/science/lipid (Accessed on Feb 15, 2021).
[10]
Bempedoic Acid and Ezetimibe. Available from: https://www.esperion.com/investors-media/press-releases/?reques (Accessed on Feb 15, 2021).
[11]
Nexletol. Available from: https://www.nytimes.com/aponline/2020/02/21/health/ap-us-med-fda-cholesterol-drug.html (Accessed on Feb 15, 2021).
[12]
McGinley L. FDA approves first non-statin pill to treat high cholesterol in almost two decades. The Washington Post Available from: https://www.washingtonpost.com/health/2020/02/21/fda-approves-first-non-statin-pill-treat-high-cholesterol-almost-two-decades/ (Accessed on Feb 15, 2021).
[13]
Nexletol. Available from: https://www.fda.gov/drugs/resources-information-approved-drugs/drug-trials-snapshots-nexletol (Accessed on Feb 15, 2021).
[14]
Bempedoic acid Classification. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Bempedoic-acid#section=MeSH-Pharmacological-Classification
[15]
Bempedoic acid. Available from: https://www.ncbi.nlm.nih.gov/mesh/68004791 (Accessed on Feb 15, 2021).
[16]
Bempedoic acid. Available from: https://www.ncbi.nlm.nih.gov/mesh/68000960 (Accessed on Feb 15, 2021).
[17]
Bempedoic acid. Available from: https://www.ncbi.nlm.nih.gov/mesh/68007004 (Accessed on Feb 15, 2021).

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