Abstract
The need to identify and characterize vulnerable atherosclerotic lesions in humans has lead to the development of various animal models of plaque vulnerability. In this review, current concepts of the vulnerable plaque as it leads to an acute coronary event are described, such as plaque rupture, erosion, intraplaque hemorrhage and neovascularization. Recently developed animal models that have attempted to reproduce these concepts are described and evaluated based on their suitability in the study of vulnerable plaques. Although certain features of plaque vulnerability have been reported in animal models, a model encompassing all aspects of the vulnerable plaque is lacking.
Keywords: intravascular ultrasound, smooth muscle cell, matrix metalloproteinases, phagocytes, atherosclerosis
Current Pharmaceutical Design
Title: Animal Models to Study Plaque Vulnerability
Volume: 13 Issue: 10
Author(s): K. Schapira, S. Heeneman and M. J. A.P. Daemen
Affiliation:
Keywords: intravascular ultrasound, smooth muscle cell, matrix metalloproteinases, phagocytes, atherosclerosis
Abstract: The need to identify and characterize vulnerable atherosclerotic lesions in humans has lead to the development of various animal models of plaque vulnerability. In this review, current concepts of the vulnerable plaque as it leads to an acute coronary event are described, such as plaque rupture, erosion, intraplaque hemorrhage and neovascularization. Recently developed animal models that have attempted to reproduce these concepts are described and evaluated based on their suitability in the study of vulnerable plaques. Although certain features of plaque vulnerability have been reported in animal models, a model encompassing all aspects of the vulnerable plaque is lacking.
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Cite this article as:
Schapira K., Heeneman S. and A.P. Daemen J. M., Animal Models to Study Plaque Vulnerability, Current Pharmaceutical Design 2007; 13 (10) . https://dx.doi.org/10.2174/138161207780487575
DOI https://dx.doi.org/10.2174/138161207780487575 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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