A Patent Review on the Use of L-Asparaginase in the Treatment of Acute Lymphocytic Leukemia

Title:A Patent Review on the Use of L-Asparaginase in the Treatment of Acute Lymphocytic Leukemia

Volume: 15 Issue: 1

Author(s): Davi Almeida Freire*, Ilana Carneiro Lisboa Magalháes, Eridan Orlando Pereira Tramontina Florean and Maria Izabel Florindo Guedes

Affiliation:

• Department of Biotechnology, Universidade Estadual do Ceará, Fortaleza,Brazil

Keywords: Acute lymphocytic leukemia, cancer, enzyme, improvement, L-asparaginase, patent, treatment, products.

Abstract: L-asparaginase (L-asparagine amino hydrolase, E.C.3.5.1.1) is the most important chemotherapeutic drug used in treating Acute Lymphocytic Leukemia (ALL), decreasing blood asparagine rates causing apoptosis in tumor cells. However, pharmacological drugs cause several side effects making treatments difficult. Thus, searches for new sources of L-asparaginase or enzyme modifications focus on discovering new products to use in therapy. This article reviewed published patents from 2000 to 2020 related to the treatment of ALL using L-asparaginase. Many organisms have been shown as potential viable L-asparaginase producers for use in the treatment of ALL. However, this patent review shows that few of these organisms are gaining attention to becoming bioproducts for the market. It is expected that drugs in the testing phase and patents related to the treatment of ALL and other cancers will become real products. Besides, a treatment using an amino acid depletion approach, now referring to asparagine, altogether with a compound that directly interferes with the expression of the asparagine synthase gene, is more suitable for the treatment of ALL and possibly to other cancers.

Cite this article as:

Freire Almeida Davi *, Lisboa Magalháes Carneiro Ilana , Tramontina Florean Orlando Pereira Eridan and Florindo Guedes Izabel Maria , A Patent Review on the Use of L-Asparaginase in the Treatment of Acute Lymphocytic Leukemia, Recent Advances in Drug Delivery and Formulation 2021; 15 (1) . https://dx.doi.org/10.2174/1872211314666210301125843