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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Evaluation of Serine Protease Inhibitors as Potent FVIIa-sTF Inhibitors in the Blood Coagulation Cascade

Author(s): Andrea Roxanne J. Anas and Ken-ichi Harada

Volume 13, Issue 1, 2016

Page: [3 - 23] Pages: 21

DOI: 10.2174/1570180812666150608230214

Price: $65

Abstract

Serine proteases are involved in the blood coagulation cascade- composed of intrinsic, extrinsic, and common pathways affecting coagulation responses. Among the three pathways of the blood coagulation cascade involving serine proteases, this review focuses on serine protease inhibitors of the understudied extrinsic pathway, which is responsible for bleeding and bleeding complications targeting the (activated factor VII-Tissue Factor) fVIIa-TF complex. In lieu of our search for fVIIa-soluble TF (fVIIa-sTF) inhibitors or scaffolds, we review the serine protease inhibitors present as synthetic and natural products, which are involved in the blood coagulation cascade, and compare them with the serine protease peptide inhibitors found in toxic Microcystis cyanobacteria. Some scaffolds for the extrinsic pathway as inhibitors from the toxic Microcystis cyanobacteria will be identified in the review.

Keywords: Cyanobacteria peptides, blood coagulation cascade, extrinsic pathway, FVIIa-sTF inhibitors, thrombin inhibitors; microcystis.

Graphical Abstract


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